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    Slc27a4 solute carrier family 27 (fatty acid transporter), member 4 [ Mus musculus (house mouse) ]

    Gene ID: 26569, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc27a4provided by MGI
    Official Full Name
    solute carrier family 27 (fatty acid transporter), member 4provided by MGI
    Primary source
    MGI:MGI:1347347
    See related
    Ensembl:ENSMUSG00000059316 AllianceGenome:MGI:1347347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FATP4; ACSVL4
    Summary
    Enables oleoyl-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Involved in glucose import in response to insulin stimulus; long-chain fatty acid import into cell; and negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Acts upstream of or within several processes, including fatty acid metabolic process; fatty acid transport; and skin development. Located in brush border membrane; endoplasmic reticulum; and microvillus. Is expressed in several structures, including alimentary system; eye; nervous system; skin; and urinary system. Used to study restrictive dermopathy. Orthologous to human SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 297.3), small intestine adult (RPKM 226.2) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc27a4 in Genome Data Viewer
    Location:
    2 B; 2 20.64 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29692646..29707534)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29802634..29817522)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TruB pseudouridine (psi) synthase family member 2 Neighboring gene STARR-seq mESC enhancer starr_04073 Neighboring gene coenzyme Q4 Neighboring gene predicted gene, 52595 Neighboring gene STARR-seq mESC enhancer starr_04075 Neighboring gene STARR-positive B cell enhancer ABC_E224 Neighboring gene ubiquitin related modifier 1 Neighboring gene microRNA 219a-2 Neighboring gene predicted gene, 54109 Neighboring gene microRNA 219b Neighboring gene cerebral endothelial cell adhesion molecule

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oleate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oleoyl-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oleoyl-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oleoyl-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables oleoyl-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables palmitoyl-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables palmitoyl-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables very long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables very long-chain fatty acid-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose import in response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid transport across blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid import into cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within long-chain fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within long-chain fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in medium-chain fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within medium-chain fatty acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within medium-chain fatty acid transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within very long-chain fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within very long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    long-chain fatty acid transport protein 4
    Names
    arachidonate--CoA ligase
    long-chain-fatty-acid--CoA ligase
    very long-chain acyl-CoA synthetase 4
    NP_036119.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011989.5NP_036119.1  long-chain fatty acid transport protein 4

      See identical proteins and their annotated locations for NP_036119.1

      Status: VALIDATED

      Source sequence(s)
      AL845323, BX294378
      Consensus CDS
      CCDS15858.1
      UniProtKB/Swiss-Prot
      O88562, Q3TD48, Q91VE0
      Related
      ENSMUSP00000078971.3, ENSMUST00000080065.3
      Conserved Domains (2) summary
      cd05939
      Location:99608
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
      PRK08279
      Location:75643
      PRK08279; long-chain-acyl-CoA synthetase; Validated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29692646..29707534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)