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    Ms4a6c membrane-spanning 4-domains, subfamily A, member 6C [ Mus musculus (house mouse) ]

    Gene ID: 73656, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ms4a6cprovided by MGI
    Official Full Name
    membrane-spanning 4-domains, subfamily A, member 6Cprovided by MGI
    Primary source
    MGI:MGI:2385644
    See related
    Ensembl:ENSMUSG00000079419 AllianceGenome:MGI:2385644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2200009H22Rik; 2210417N07Rik
    Summary
    Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane and trans-Golgi network. Orthologous to several human genes including MS4A6A (membrane spanning 4-domains A6A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 3.1), mammary gland adult (RPKM 1.9) and 20 other tissues See more
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    Genomic context

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    See Ms4a6c in Genome Data Viewer
    Location:
    19 A; 19 8.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11446718..11464433)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11469353..11487182)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene membrane-spanning 4-domains, subfamily A, member 4B Neighboring gene expressed sequence BE692007 Neighboring gene STARR-positive B cell enhancer ABC_E7634 Neighboring gene STARR-positive B cell enhancer ABC_E4266 Neighboring gene STARR-positive B cell enhancer ABC_E11672 Neighboring gene STARR-positive B cell enhancer ABC_E8739 Neighboring gene predicted gene 8369 Neighboring gene membrane-spanning 4-domains, subfamily A, member 6B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Liang Y, et al. Genomics, 2001 Mar 1. PMID 11401424
    2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    membrane-spanning 4-domains subfamily A member 6C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166376.1 → NP_001159848.1  membrane-spanning 4-domains subfamily A member 6C isoform 2

      See identical proteins and their annotated locations for NP_001159848.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 3' end, compared to variant 1. These differences produce a unique 3' coding region and 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      BC062247, BY164174
      UniProtKB/TrEMBL
      Q6P6F8
      Related
      ENSMUST00000187462.2
      Conserved Domains (1) summary
      pfam04103
      Location:47 → 95
      CD20; CD20-like family

    2. NM_028595.4 → NP_082871.2  membrane-spanning 4-domains subfamily A member 6C isoform 1

      See identical proteins and their annotated locations for NP_082871.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK150397, AK152258, BY164174, BY691481
      Consensus CDS
      CCDS50395.1
      UniProtKB/Swiss-Prot
      Q3U8E1, Q8BVZ4, Q99N08, Q9D7Z9
      Related
      ENSMUSP00000132425.2, ENSMUST00000165310.3
      Conserved Domains (1) summary
      pfam04103
      Location:47 → 207
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      11446718..11464433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527381.5 → XP_006527444.1  membrane-spanning 4-domains subfamily A member 6C isoform X1

      Conserved Domains (1) summary
      pfam04103
      Location:50 → 207
      CD20; CD20-like family

    RNA

    1. XR_877690.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N08.1 GenPept UniProtKB/Swiss-Prot:Q99N08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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