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    Gtf2i general transcription factor II I [ Mus musculus (house mouse) ]

    Gene ID: 14886, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gtf2iprovided by MGI
    Official Full Name
    general transcription factor II Iprovided by MGI
    Primary source
    MGI:MGI:1202722
    See related
    Ensembl:ENSMUSG00000060261 AllianceGenome:MGI:1202722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spin; Diws1t; TFII-I; WBSCR6; BAP-135; GtfII-I; 6030441I21Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in negative regulation of cytosolic calcium ion concentration and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of angiogenesis. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; respiratory system; and tooth. Used to study Williams-Beuren syndrome. Orthologous to human GTF2I (general transcription factor IIi). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 36.6), limb E14.5 (RPKM 32.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gtf2i in Genome Data Viewer
    Location:
    5 G2; 5 74.48 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134266686..134346571, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134237832..134317678, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E105 Neighboring gene STARR-positive B cell enhancer ABC_E4791 Neighboring gene GTF2I repeat domain containing 2 Neighboring gene predicted gene, 57734 Neighboring gene STARR-positive B cell enhancer mm9_chr5:134712733-134713034 Neighboring gene neutrophil cytosolic factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E8084 Neighboring gene STARR-seq mESC enhancer starr_14530 Neighboring gene STARR-seq mESC enhancer starr_14534 Neighboring gene microRNA 3965 Neighboring gene predicted gene, 46925

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • 6030441I21Rik

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    general transcription factor II-I
    Names
    BTK-associated protein 135
    Bruton tyrosine kinase-associated protein 135
    SRF-Phox1-interacting protein
    Williams-Beuren syndrome chromosomal region 6 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080746.2NP_001074215.1  general transcription factor II-I isoform 1

      See identical proteins and their annotated locations for NP_001074215.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as Gamma).
      Source sequence(s)
      AC093346, BC053044, CB250008
      Consensus CDS
      CCDS39301.1
      UniProtKB/Swiss-Prot
      O54700, O55030, O55031, Q8VHD1, Q8VHD2, Q8VHD3, Q8VHD4, Q9CSB5, Q9D9K9, Q9ESZ8
      UniProtKB/TrEMBL
      G3UYD0
      Related
      ENSMUSP00000049625.8, ENSMUST00000059042.15
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    2. NM_001080747.2NP_001074216.1  general transcription factor II-I isoform 3

      See identical proteins and their annotated locations for NP_001074216.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3, also known as Alpha) is shorter than isoform 1.
      Source sequence(s)
      AC093346, BC053044, CB250008
      Consensus CDS
      CCDS39300.1
      UniProtKB/TrEMBL
      G3UYD0
      Related
      ENSMUSP00000080714.4, ENSMUST00000082057.10
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    3. NM_001080748.2NP_001074217.1  general transcription factor II-I isoform 4

      See identical proteins and their annotated locations for NP_001074217.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (4, also known as Delta or Short) is shorter than isoform 1.
      Source sequence(s)
      AC093346, BC053044, CB250008
      Consensus CDS
      CCDS57386.1
      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    4. NM_001080749.2NP_001074218.1  general transcription factor II-I isoform 5

      See identical proteins and their annotated locations for NP_001074218.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC093346, AK147201, CB250008, MG954273
      Consensus CDS
      CCDS57387.1
      UniProtKB/TrEMBL
      G3UYD0, Q3UHU8
      Related
      ENSMUSP00000133444.2, ENSMUST00000173341.9
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    5. NM_001359062.1NP_001345991.1  general transcription factor II-I isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC093346, CB250008, MG954273
      Consensus CDS
      CCDS39301.1
      UniProtKB/Swiss-Prot
      O54700, O55030, O55031, Q8VHD1, Q8VHD2, Q8VHD3, Q8VHD4, Q9CSB5, Q9D9K9, Q9ESZ8
      UniProtKB/TrEMBL
      G3UYD0
      Related
      ENSMUSP00000133566.2, ENSMUST00000174155.8
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    6. NM_001359063.1NP_001345992.1  general transcription factor II-I isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 2 and 8, encodes isoform 2.
      Source sequence(s)
      AC093346, CB250008, MG954273
      Consensus CDS
      CCDS39299.1
      UniProtKB/TrEMBL
      G3UYD0
      Related
      ENSMUSP00000134440.2, ENSMUST00000174354.8
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    7. NM_001359064.1NP_001345993.1  general transcription factor II-I isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 2 and 7, encodes isoform 2.
      Source sequence(s)
      AC093346
      Consensus CDS
      CCDS39299.1
      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    8. NM_001359065.1NP_001345994.1  general transcription factor II-I isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variant 3, encodes isoform 3.
      Source sequence(s)
      AC093346, CB250008, MG954273
      Consensus CDS
      CCDS39300.1
      UniProtKB/TrEMBL
      G3UYD0
      Related
      ENSMUSP00000133740.2, ENSMUST00000174772.8
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    9. NM_001359066.1NP_001345995.1  general transcription factor II-I isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 4 and 11, encodes isoform 4.
      Source sequence(s)
      AC093346, CB250008, MG954273
      Consensus CDS
      CCDS57386.1
      UniProtKB/TrEMBL
      G3UYD0
      Related
      ENSMUSP00000133489.2, ENSMUST00000174513.8
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    10. NM_001359067.1NP_001345996.1  general transcription factor II-I isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variant 4 and 10, encodes isoform 4.
      Source sequence(s)
      AC093346
      Consensus CDS
      CCDS57386.1
      UniProtKB/TrEMBL
      G3UYD0
      Related
      ENSMUSP00000133969.2, ENSMUST00000173888.8
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    11. NM_010365.4NP_034495.2  general transcription factor II-I isoform 2

      See identical proteins and their annotated locations for NP_034495.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2, also known as Beta or Long) is shorter than isoform 1.
      Source sequence(s)
      AC093346, BC053044, CB250008
      Consensus CDS
      CCDS39299.1
      UniProtKB/TrEMBL
      G3UYD0
      Related
      ENSMUSP00000106892.5, ENSMUST00000111261.12
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      134266686..134346571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254157.2XP_030110017.1  general transcription factor II-I isoform X15

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    2. XM_006504386.2XP_006504449.1  general transcription factor II-I isoform X4

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    3. XM_006504389.2XP_006504452.1  general transcription factor II-I isoform X6

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    4. XM_006504384.2XP_006504447.1  general transcription factor II-I isoform X1

      See identical proteins and their annotated locations for XP_006504447.1

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    5. XM_006504385.2XP_006504448.1  general transcription factor II-I isoform X3

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    6. XM_030254165.2XP_030110025.1  general transcription factor II-I isoform X23

      UniProtKB/TrEMBL
      G3UYD0
      Related
      ENSMUSP00000134035.2, ENSMUST00000172715.8
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    7. XM_030254163.2XP_030110023.1  general transcription factor II-I isoform X22

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    8. XM_036164817.1XP_036020710.1  general transcription factor II-I isoform X19

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    9. XM_036164818.1XP_036020711.1  general transcription factor II-I isoform X20

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    10. XM_030254159.2XP_030110019.1  general transcription factor II-I isoform X16

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    11. XM_036164815.1XP_036020708.1  general transcription factor II-I isoform X18

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    12. XM_030254161.2XP_030110021.1  general transcription factor II-I isoform X21

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    13. XM_036164813.1XP_036020706.1  general transcription factor II-I isoform X12

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    14. XM_030254148.2XP_030110008.1  general transcription factor II-I isoform X7

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    15. XM_036164810.1XP_036020703.1  general transcription factor II-I isoform X9

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    16. XM_030254155.2XP_030110015.1  general transcription factor II-I isoform X10

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    17. XM_036164806.1XP_036020699.1  general transcription factor II-I isoform X5

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    18. XM_030254147.2XP_030110007.1  general transcription factor II-I isoform X2

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    19. XM_030254156.2XP_030110016.1  general transcription factor II-I isoform X13

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    20. XM_006504391.2XP_006504454.1  general transcription factor II-I isoform X14

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    21. XM_030254153.2XP_030110013.1  general transcription factor II-I isoform X8

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    22. XM_017320677.2XP_017176166.1  general transcription factor II-I isoform X11

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    23. XM_030254162.2XP_030110022.1  general transcription factor II-I isoform X21

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    24. XM_036164803.1XP_036020696.1  general transcription factor II-I isoform X2

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    25. XM_030254145.2XP_030110005.1  general transcription factor II-I isoform X1

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    26. XM_030254144.2XP_030110004.1  general transcription factor II-I isoform X1

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    27. XM_036164808.1XP_036020701.1  general transcription factor II-I isoform X7

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    28. XM_036164804.1XP_036020697.1  general transcription factor II-I isoform X2

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    29. XM_030254154.2XP_030110014.1  general transcription factor II-I isoform X8

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    30. XM_030254146.2XP_030110006.1  general transcription factor II-I isoform X1

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    31. XM_036164802.1XP_036020695.1  general transcription factor II-I isoform X2

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    32. XM_036164809.1XP_036020702.1  general transcription factor II-I isoform X8

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    33. XM_030254140.2XP_030110000.1  general transcription factor II-I isoform X1

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    34. XM_030254141.2XP_030110001.1  general transcription factor II-I isoform X1

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    35. XM_030254164.2XP_030110024.1  general transcription factor II-I isoform X22

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    36. XM_030254158.2XP_030110018.1  general transcription factor II-I isoform X15

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    37. XM_036164805.1XP_036020698.1  general transcription factor II-I isoform X3

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    38. XM_030254151.2XP_030110011.1  general transcription factor II-I isoform X7

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    39. XM_036164814.1XP_036020707.1  general transcription factor II-I isoform X12

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    40. XM_036164807.1XP_036020700.1  general transcription factor II-I isoform X6

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    41. XM_036164819.1XP_036020712.1  general transcription factor II-I isoform X20

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    42. XM_036164816.1XP_036020709.1  general transcription factor II-I isoform X18

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    43. XM_017320681.3XP_017176170.1  general transcription factor II-I isoform X17

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    44. XM_036164811.1XP_036020704.1  general transcription factor II-I isoform X9

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat
    45. XM_036164812.1XP_036020705.1  general transcription factor II-I isoform X9

      UniProtKB/TrEMBL
      G3UYD0
      Conserved Domains (1) summary
      pfam02946
      Location:112186
      GTF2I; GTF2I-like repeat