IDP3 isocitrate dehydrogenase (NADP(+)) IDP3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: IDP3
Official Full Name: isocitrate dehydrogenase (NADP(+)) IDP3
Primary source: SGD:S000004954
Locus tag: YNL009W
See related: AllianceGenome:SGD:S000004954; FungiDB:YNL009W; VEuPathDB:YNL009W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables isocitrate dehydrogenase (NADP+) activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Human ortholog(s) of this gene implicated in several diseases, including D-2-hydroxyglutaric aciduria 2; carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and lung cancer (multiple). Orthologous to several human genes including IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See IDP3 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (614821..616083)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The S. cerevisiae (Sc) Idp1, Idp2, and Idp3 are highly similar to Homo sapiens (Hs) Idh1 and Idh2 (67, 60 and 59% amino acid identity between Sc Idp1, Idp2, and Idp3, and Hs Idh1, respectively), and the arginine residues corresponding to R100 and R132 in Hs Idh1 (Hs Idh2 R140 and R172) are conserved in the corresponding yeast orthologs
Title: Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
Peroxisomal localization and function of NADP+ -specific isocitrate dehydrogenases in yeast.
Title: Peroxisomal localization and function of NADP+ -specific isocitrate dehydrogenases in yeast.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables isocitrate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glyoxylate cycle	IEA Inferred from Electronic Annotation more info
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isocitrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: isocitrate dehydrogenase (NADP(+)) IDP3

NP_014389.3

EC 1.1.1.42

Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

614821..616083

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182848.3 → NP_014389.3 TPA: isocitrate dehydrogenase (NADP(+)) IDP3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014389.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1G8, P53982

UniProtKB/TrEMBL

A6ZS67, N1NWR1

Conserved Domains (1) summary

PRK08299
Location:1 → 407

PRK08299; NADP-dependent isocitrate dehydrogenase