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    Ntng2 netrin G2 [ Mus musculus (house mouse) ]

    Gene ID: 171171, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ntng2provided by MGI
    Official Full Name
    netrin G2provided by MGI
    Primary source
    MGI:MGI:2159341
    See related
    Ensembl:ENSMUSG00000035513 AllianceGenome:MGI:2159341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lmnt2; 2610016D08Rik
    Summary
    The protein encoded by this gene belongs to a subclass of the netrin family called netrin-G proteins. Unlike classic netrins, which act as diffusible chemoattractants, netrin-Gs are glycosylphosphatidylinositol-anchored membrane proteins that interact with specific transmembrane proteins. In mouse, this gene is preferentially expressed in the cerebral cortex, habenular nucleus and superior colliculus. Knockout mutant mice display a lack of behavioral startle in response to acoustic stimuli. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Broad expression in adrenal adult (RPKM 73.1), ovary adult (RPKM 25.0) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ntng2 in Genome Data Viewer
    Location:
    2 B; 2 19.57 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29084738..29138111, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29194726..29248099, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04038 Neighboring gene STARR-seq mESC enhancer starr_04039 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:28980423-28980610 Neighboring gene STARR-positive B cell enhancer ABC_E5902 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04042 Neighboring gene STARR-seq mESC enhancer starr_04043 Neighboring gene senataxin Neighboring gene STARR-seq mESC enhancer starr_04046 Neighboring gene RIKEN cDNA 6530402F18 gene Neighboring gene STARR-seq mESC enhancer starr_04048 Neighboring gene STARR-seq mESC enhancer starr_04049 Neighboring gene STARR-positive B cell enhancer ABC_E4423 Neighboring gene mediator complex subunit 27 Neighboring gene STARR-seq mESC enhancer starr_04051 Neighboring gene STARR-seq mESC enhancer starr_04052 Neighboring gene microRNA 133c Neighboring gene predicted gene, 30761

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305805.2NP_001292734.1  netrin-G2 isoform c precursor

      See identical proteins and their annotated locations for NP_001292734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) lacks an in-frame exon in the 3' coding region compared to variant b. It encodes isoform c, which is shorter than isoform b.
      Source sequence(s)
      AL772379
      Consensus CDS
      CCDS84499.1
      Related
      ENSMUSP00000088688.3, ENSMUST00000091153.9
      Conserved Domains (4) summary
      cd00055
      Location:286332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:444491
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:491521
      EGF_2; EGF-like domain
    2. NM_133500.3NP_598007.1  netrin-G2 isoform a precursor

      See identical proteins and their annotated locations for NP_598007.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) lacks two in-frame exons in the 3' coding region compared to variant b. It encodes isoform a, which is shorter than isoform b.
      Source sequence(s)
      AL772379
      Consensus CDS
      CCDS15851.1
      UniProtKB/TrEMBL
      A2AKW8
      Related
      ENSMUSP00000099937.2, ENSMUST00000102873.8
      Conserved Domains (4) summary
      cd00055
      Location:286332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:410457
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:457487
      EGF_2; EGF-like domain
    3. NM_133501.3NP_598008.1  netrin-G2 isoform b precursor

      See identical proteins and their annotated locations for NP_598008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) represents the longest transcript and encodes the longest isoform (b).
      Source sequence(s)
      AL772379
      Consensus CDS
      CCDS15852.1
      UniProtKB/Swiss-Prot
      A2AKX0, Q8R4F1, Q8R4F2, Q8VIP6, Q8VIP7, Q8VIP8
      Related
      ENSMUSP00000035468.3, ENSMUST00000048455.9
      Conserved Domains (4) summary
      cd00055
      Location:286332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:469516
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:516546
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29084738..29138111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)