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    Tshz2 teashirt zinc finger family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 228911, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tshz2provided by MGI
    Official Full Name
    teashirt zinc finger family member 2provided by MGI
    Primary source
    MGI:MGI:2153084
    See related
    Ensembl:ENSMUSG00000047907 AllianceGenome:MGI:2153084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsh2; Mtsh2; Zfp218; Sdccag33l; mKIAA4248; teashirt2; B830045G17; 2900073F20Rik
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including forelimb; ganglionic eminence; genitourinary system; heart valve; and limb bud. Orthologous to human TSHZ2 (teashirt zinc finger homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 8.3), bladder adult (RPKM 7.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tshz2 in Genome Data Viewer
    Location:
    2 H3; 2 89.47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (169474430..169914671)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (169632509..170072751)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 34112 Neighboring gene predicted gene 14249 Neighboring gene STARR-seq mESC enhancer starr_06491 Neighboring gene VISTA enhancer mm1064 Neighboring gene predicted gene, 34294 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169520657-169520858 Neighboring gene predicted gene, 34344 Neighboring gene STARR-seq mESC enhancer starr_06492 Neighboring gene predicted gene, 54131 Neighboring gene STARR-seq mESC enhancer starr_06495 Neighboring gene STARR-seq mESC enhancer starr_06496 Neighboring gene STARR-seq mESC enhancer starr_06499 Neighboring gene STARR-seq mESC enhancer starr_06500 Neighboring gene STARR-seq mESC enhancer starr_06501 Neighboring gene cDNA sequence AY702102 Neighboring gene STARR-seq mESC enhancer starr_06502 Neighboring gene STARR-seq mESC enhancer starr_06503 Neighboring gene RIKEN cDNA A630075F10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169978978-169979087 Neighboring gene STARR-positive B cell enhancer ABC_E9210 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169980510-169980753 Neighboring gene STARR-positive B cell enhancer ABC_E10165 Neighboring gene STARR-positive B cell enhancer ABC_E2658 Neighboring gene zinc finger protein 217 Neighboring gene predicted gene, 34403

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Transposon induced (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4248

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    teashirt homolog 2
    Names
    SDCCAG33-like protein
    serologically defined colon cancer antigen 33 like
    teashirt 2
    zinc finger protein 218

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363022.2NP_001349951.1  teashirt homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL731822, AL731826
      Consensus CDS
      CCDS50805.1
      UniProtKB/Swiss-Prot
      Q5DTF1, Q68FE9, Q6AXH5, Q9JL71
      Conserved Domains (1) summary
      cd00086
      Location:838906
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    2. NM_001363023.2NP_001349952.1  teashirt homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL731822, AL731826
      Consensus CDS
      CCDS50805.1
      UniProtKB/Swiss-Prot
      Q5DTF1, Q68FE9, Q6AXH5, Q9JL71
      Related
      ENSMUSP00000104787.3, ENSMUST00000109159.3
      Conserved Domains (1) summary
      cd00086
      Location:838906
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    3. NM_080455.4NP_536703.2  teashirt homolog 2 isoform a

      See identical proteins and their annotated locations for NP_536703.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL731822, AL731826
      Consensus CDS
      CCDS50805.1
      UniProtKB/Swiss-Prot
      Q5DTF1, Q68FE9, Q6AXH5, Q9JL71
      Related
      ENSMUSP00000104785.2, ENSMUST00000109157.2
      Conserved Domains (1) summary
      cd00086
      Location:838906
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    4. NM_177659.2NP_808327.1  teashirt homolog 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 1. The resulting isoform (b) is shorter at the C-terminus compared to isoform a.
      Source sequence(s)
      AL731822, AL731826
      Conserved Domains (2) summary
      cd00086
      Location:838906
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:218240
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      169474430..169914671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161701.1XP_036017594.1  teashirt homolog 2 isoform X4

      Conserved Domains (2) summary
      cd00086
      Location:838906
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:218240
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_006499424.5XP_006499487.2  teashirt homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006499487.2

      Conserved Domains (2) summary
      cd00086
      Location:858926
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_006499426.5XP_006499489.2  teashirt homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_006499489.2

      Conserved Domains (2) summary
      cd00086
      Location:858926
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_006499423.5XP_006499486.2  teashirt homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006499486.2

      Conserved Domains (2) summary
      cd00086
      Location:858926
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_006499425.5XP_006499488.2  teashirt homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_006499488.2

      Conserved Domains (2) summary
      cd00086
      Location:858926
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. XM_030250745.2XP_030106605.1  teashirt homolog 2 isoform X1

      Conserved Domains (2) summary
      cd00086
      Location:858926
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]