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    Usp14 ubiquitin specific peptidase 14 [ Mus musculus (house mouse) ]

    Gene ID: 59025, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp14provided by MGI
    Official Full Name
    ubiquitin specific peptidase 14provided by MGI
    Primary source
    MGI:MGI:1928898
    See related
    Ensembl:ENSMUSG00000047879 AllianceGenome:MGI:1928898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ax; nmf375; 2610005K12Rik; 2610037B11Rik
    Summary
    Predicted to enable deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Acts upstream of or within chemical synaptic transmission. Located in synapse. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 14.6), cortex adult (RPKM 14.0) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Usp14 in Genome Data Viewer
    Location:
    18 A1; 18 4.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (9993615..10030149, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (9993615..10030149, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43785 Neighboring gene cell division cycle associated 7 pseudogene Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43786 Neighboring gene THO complex 1 Neighboring gene STARR-seq mESC enhancer starr_43787 Neighboring gene STARR-seq mESC enhancer starr_43788 Neighboring gene STARR-seq mESC enhancer starr_43789 Neighboring gene Rho-associated coiled-coil containing protein kinase 1 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene predicted gene, 26244

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Spontaneous (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proteasome binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic cytosol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in presynaptic cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in presynaptic cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 14
    Names
    ataxia
    dUB-type TGT for deubiquitinating enzyme
    deubiquitinating enzyme 14
    ubiquitin specific protease 14
    ubiquitin thioesterase 14
    ubiquitin thiolesterase 14
    ubiquitin-specific-processing protease 14
    NP_001033678.1
    NP_001347813.1
    NP_067497.2
    XP_006526197.1
    XP_030106415.1
    XP_030106416.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038589.2NP_001033678.1  ubiquitin carboxyl-terminal hydrolase 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163451, CB520876, CJ161902, CK621440, CN531861
      Consensus CDS
      CCDS37734.1
      UniProtKB/TrEMBL
      E9PYI8, Q80UN0
      Related
      ENSMUSP00000112368.2, ENSMUST00000116669.2
      Conserved Domains (3) summary
      cd02657
      Location:71445
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00443
      Location:69444
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00155
      Location:564
      UBQ; Ubiquitin-like proteins
    2. NM_001360884.1NP_001347813.1  ubiquitin carboxyl-terminal hydrolase 14 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163451
      UniProtKB/TrEMBL
      Q80UN0
      Conserved Domains (2) summary
      cd02657
      Location:45419
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cl28922
      Location:139
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    3. NM_021522.4NP_067497.2  ubiquitin carboxyl-terminal hydrolase 14 isoform 1

      See identical proteins and their annotated locations for NP_067497.2

      Status: VALIDATED

      Source sequence(s)
      AC163451, AK011322, AK029977, CJ161902
      Consensus CDS
      CCDS37735.1
      UniProtKB/Swiss-Prot
      Q543U5, Q923F2, Q9D0L0, Q9JMA1
      UniProtKB/TrEMBL
      Q80UN0
      Related
      ENSMUSP00000089728.7, ENSMUST00000092096.14
      Conserved Domains (4) summary
      smart00213
      Location:574
      UBQ; Ubiquitin homologues
      cd02657
      Location:106480
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00443
      Location:104479
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00155
      Location:574
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      9993615..10030149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250556.2XP_030106416.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X2

      UniProtKB/TrEMBL
      Q80UN0
      Conserved Domains (2) summary
      cd02657
      Location:45419
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cl28922
      Location:139
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. XM_030250555.1XP_030106415.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X1

      UniProtKB/TrEMBL
      Q80UN0
      Conserved Domains (2) summary
      cd02657
      Location:80454
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cd16104
      Location:150
      Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins
    3. XM_006526134.5XP_006526197.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X1

      UniProtKB/TrEMBL
      Q80UN0
      Conserved Domains (2) summary
      cd02657
      Location:80454
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cd16104
      Location:150
      Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins