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    Fmn2 formin 2 [ Mus musculus (house mouse) ]

    Gene ID: 54418, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fmn2provided by MGI
    Official Full Name
    formin 2provided by MGI
    Primary source
    MGI:MGI:1859252
    See related
    Ensembl:ENSMUSG00000028354 AllianceGenome:MGI:1859252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin binding activity. Involved in several processes, including cytoskeleton organization; meiotic nuclear division; and oogenesis. Acts upstream of or within actin filament bundle assembly and meiotic chromosome movement towards spindle pole. Located in several cellular components, including endoplasmic reticulum membrane; microvillus; and spindle. Is expressed in several structures, including brain; ganglia; neural ectoderm; otocyst; and testis. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 47. Orthologous to human FMN2 (formin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 7.4), cortex adult (RPKM 7.0) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Fmn2 in Genome Data Viewer
    Location:
    1 H3; 1 81.04 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (174324079..174650295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (174501752..174822729)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:176399948-176400249 Neighboring gene STARR-seq mESC enhancer starr_03089 Neighboring gene STARR-seq mESC enhancer starr_03090 Neighboring gene STARR-seq mESC enhancer starr_03091 Neighboring gene STARR-seq mESC enhancer starr_03092 Neighboring gene olfactory receptor family 6 subfamily P member 1 Neighboring gene olfactory receptor family 6 subfamily Y member 1 Neighboring gene STARR-seq mESC enhancer starr_03094 Neighboring gene lines homolog 2 pseudogene Neighboring gene predicted gene, 51689 Neighboring gene STARR-seq mESC enhancer starr_03095 Neighboring gene gremlin 2, DAN family BMP antagonist Neighboring gene STARR-seq mESC enhancer starr_03096 Neighboring gene STARR-seq mESC enhancer starr_03097 Neighboring gene STARR-seq mESC enhancer starr_03098 Neighboring gene STARR-seq mESC enhancer starr_03100 Neighboring gene regulator of G protein signaling 7 Neighboring gene predicted gene, 53483

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of meiotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in formin-nucleated actin cable assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in formin-nucleated actin cable assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in formin-nucleated actin cable assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in homologous chromosome movement towards spindle pole in meiosis I anaphase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within meiotic chromosome movement towards spindle pole IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019445.2NP_062318.2  formin-2

      See identical proteins and their annotated locations for NP_062318.2

      Status: VALIDATED

      Source sequence(s)
      BC094606, BM228488, BP758042
      Consensus CDS
      CCDS48459.1
      UniProtKB/Swiss-Prot
      Q505D3, Q9JL04
      Related
      ENSMUSP00000030039.8, ENSMUST00000030039.13
      Conserved Domains (1) summary
      pfam02181
      Location:11391529
      FH2; Formin Homology 2 Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      174324079..174650295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152433.1XP_036008326.1  formin-2 isoform X1

      Conserved Domains (2) summary
      PTZ00449
      Location:213450
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl19758
      Location:11391216
      FH2; Formin Homology 2 Domain
    2. XM_030255545.1XP_030111405.1  formin-2 isoform X2

      Conserved Domains (1) summary
      pfam02181
      Location:6341024
      FH2; Formin Homology 2 Domain