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    gcna-1 Germ cell nuclear acidic-1 protein [ Caenorhabditis elegans ]

    Gene ID: 175850, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcna-1
    Official Full Name
    Germ cell nuclear acidic-1 protein
    Primary source
    WormBase:WBGene00022694
    Locus tag
    CELE_ZK328.4
    See related
    AllianceGenome:WB:WBGene00022694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables SUMO polymer binding activity. Involved in meiotic chromosome segregation and protein-DNA covalent cross-linking repair. Located in PML body and condensed chromosome. Is expressed in Z2; Z3; and germ cell. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 4. Orthologous to human GCNA (germ cell nuclear acidic peptidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcna-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (6006344..6009084, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Rho GTPase-activating protein 26;SH3 domain-containing protein Neighboring gene ncRNA Neighboring gene Tr-type G domain-containing protein Neighboring gene Nuclear pore complex protein Nup98 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUMOylation promotes protective responses to DNA-protein crosslinks. Borgermann N, et al. EMBO J, 2019 Apr 15. PMID 30914427, Free PMC Article
    2. A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. Carmell MA, et al. Elife, 2016 Oct 8. PMID 27718356, Free PMC Article
    3. GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability. Dokshin GA, et al. Dev Cell, 2020 Jan 6. PMID 31839538, Free PMC Article
    4. GCNA Preserves Genome Integrity and Fertility Across Species. Bhargava V, et al. Dev Cell, 2020 Jan 6. PMID 31839537, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SUMO polymer binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-DNA covalent cross-linking repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Germ cell nuclear acidic-1 protein
    NP_498307.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6006344..6009084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065906.5 → NP_498307.1  Germ cell nuclear acidic-1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498307.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23462
      Conserved Domains (1) summary
      smart00731
      Location:296 → 451
      SprT; SprT homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23462.2

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