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    TAF9 chromatin modification protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855276, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TAF9
    Official Full Name
    chromatin modification protein
    Primary source
    SGD:S000004849
    Locus tag
    YMR236W
    See related
    AllianceGenome:SGD:S000004849; FungiDB:YMR236W; VEuPathDB:YMR236W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TAF17
    Summary
    Enables chromatin binding activity and molecular adaptor activity. Involved in RNA polymerase II preinitiation complex assembly and chromatin organization. Part of SAGA complex; SLIK (SAGA-like) complex; and transcription factor TFIID complex. Orthologous to several human genes including TAF9 (TATA-box binding protein associated factor 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TAF9 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (742971..743444)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene RNA-DNA hybrid ribonuclease Neighboring gene GTPase-activating protein RNA1 Neighboring gene exomer complex subunit Neighboring gene putative mannan endo-1,6-alpha-mannosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Broad, but not universal, transcriptional requirement for yTAFII17, a histone H3-like TAFII present in TFIID and SAGA. Apone LM, et al. Mol Cell, 1998 Nov. PMID 9844637
    2. A yeast taf17 mutant requires the Swi6 transcriptional activator for viability and shows defects in cell cycle-regulated transcription. Macpherson N, et al. Genetics, 2000 Apr. PMID 10747053, Free PMC Article
    3. Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeast. Keaveney M, et al. Mol Cell, 1998 May. PMID 9660975
    4. A histone fold TAF octamer within the yeast TFIID transcriptional coactivator. Selleck W, et al. Nat Struct Biol, 2001 Aug. PMID 11473260
    5. TAF-Containing and TAF-independent forms of transcriptionally active TBP in vivo. Kuras L, et al. Science, 2000 May 19. PMID 10818000

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest a crucial role for the Taf9 C-terminal conserved region domain in genome-wide transcription and highlight the importance of conserved domains, other than histone fold domains, as a common determinant for TFIID and SAGA functions.
      Title: The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.
    2. May have role in transcription elongation, and may be involved in cell cycle and growth control.
      Title: TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SLIK (SAGA-like) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chromatin modification protein
    NP_013963.1
    • Subunit (17 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      742971..743444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182743.1 → NP_013963.1  TPA: chromatin modification protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013963.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W062, Q05027
      UniProtKB/TrEMBL
      A6ZMU9, B3LMC5, C7GRB5, C8ZFA1, G2WKU4, N1NZ24
      Conserved Domains (1) summary
      COG5094
      Location:1 → 157
      TAF9; Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05027.1

    Gene LinkOut

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