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    Wdr20 WD repeat domain 20 [ Mus musculus (house mouse) ]

    Gene ID: 69641, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr20provided by MGI
    Official Full Name
    WD repeat domain 20provided by MGI
    Primary source
    MGI:MGI:1916891
    See related
    Ensembl:ENSMUSG00000037957 AllianceGenome:MGI:1916891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr20a; 2310040A13Rik
    Summary
    Predicted to enable deubiquitinase activator activity. Predicted to be located in cytoplasm and nucleus. Orthologous to human WDR20 (WD repeat domain 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.4), thymus adult (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wdr20 in Genome Data Viewer
    Location:
    12 F1; 12 60.78 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110701459..110770709)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110735025..110804275)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53768 Neighboring gene STARR-positive B cell enhancer mm9_chr12:111934512-111934812 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111945270-111945457 Neighboring gene STARR-seq mESC enhancer starr_33300 Neighboring gene STARR-seq mESC enhancer starr_33301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111976119-111976302 Neighboring gene STARR-seq mESC enhancer starr_33302 Neighboring gene STARR-positive B cell enhancer ABC_E5355 Neighboring gene MOK protein kinase Neighboring gene STARR-seq mESC enhancer starr_33307 Neighboring gene RIKEN cDNA 4921507G05 gene Neighboring gene STARR-positive B cell enhancer ABC_E5356 Neighboring gene STARR-positive B cell enhancer ABC_E1865 Neighboring gene STARR-positive B cell enhancer ABC_E4044 Neighboring gene nuclear encoded tRNA isoleucine 6 (anticodon AAT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Yu C, et al. Science, 2013 Dec 20. PMID 24357321
    2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables deubiquitinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 20
    Names
    WD repeat domain 20A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347428.2 → NP_001334357.1  WD repeat-containing protein 20 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK009711, BP753580
      Consensus CDS
      CCDS84002.1
      UniProtKB/TrEMBL
      A0A0A6YX87, Q9D721
      Related
      ENSMUSP00000141678.2, ENSMUST00000193053.6

    2. NM_001364272.1 → NP_001351201.1  WD repeat-containing protein 20 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596265
      UniProtKB/TrEMBL
      A0A1Y7VJI5
      Conserved Domains (2) summary
      sd00039
      Location:113 → 178
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:109 → 274
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001364273.1 → NP_001351202.1  WD repeat-containing protein 20 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596265
      UniProtKB/TrEMBL
      A0A1Y7VJI5
      Conserved Domains (2) summary
      sd00039
      Location:12 → 77
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:8 → 173
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_027149.4 → NP_081425.2  WD repeat-containing protein 20 isoform 1

      See identical proteins and their annotated locations for NP_081425.2

      Status: VALIDATED

      Source sequence(s)
      AI303487, AK136417, BC064773
      Consensus CDS
      CCDS26173.1
      UniProtKB/TrEMBL
      Q3ULP2, Q3UWE6
      Related
      ENSMUSP00000093059.3, ENSMUST00000095410.8
      Conserved Domains (3) summary
      COG2319
      Location:147 → 389
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:153 → 218
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:149 → 314
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      110701459..110770709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516203.4 → XP_006516266.1  WD repeat-containing protein 20 isoform X1

      UniProtKB/TrEMBL
      Q3ULP2
      Conserved Domains (2) summary
      sd00039
      Location:153 → 218
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:149 → 314
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006516204.4 → XP_006516267.1  WD repeat-containing protein 20 isoform X2

      UniProtKB/TrEMBL
      Q3ULP2
      Conserved Domains (2) summary
      sd00039
      Location:153 → 218
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:149 → 314
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_036157607.1 → XP_036013500.1  WD repeat-containing protein 20 isoform X7

      UniProtKB/TrEMBL
      A0A0A6YX87

    4. XM_036157606.1 → XP_036013499.1  WD repeat-containing protein 20 isoform X7

      UniProtKB/TrEMBL
      A0A0A6YX87

    5. XM_006516205.4 → XP_006516268.1  WD repeat-containing protein 20 isoform X3

      UniProtKB/TrEMBL
      A0A1Y7VJI5
      Conserved Domains (2) summary
      sd00039
      Location:113 → 178
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:109 → 274
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_036157605.1 → XP_036013498.1  WD repeat-containing protein 20 isoform X4

      UniProtKB/TrEMBL
      A0A1Y7VJI5
      Conserved Domains (2) summary
      sd00039
      Location:113 → 178
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:109 → 274
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_030246901.1 → XP_030102761.1  WD repeat-containing protein 20 isoform X6

      UniProtKB/TrEMBL
      A0A1Y7VJI5
      Conserved Domains (2) summary
      sd00039
      Location:50 → 86
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:47 → 146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_011244170.4 → XP_011242472.1  WD repeat-containing protein 20 isoform X5

      See identical proteins and their annotated locations for XP_011242472.1

      UniProtKB/TrEMBL
      A0A1Y7VJI5
      Conserved Domains (2) summary
      sd00039
      Location:12 → 77
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:8 → 173
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. XM_006516207.5 → XP_006516270.1  WD repeat-containing protein 20 isoform X6

      UniProtKB/TrEMBL
      A0A1Y7VJI5
      Conserved Domains (2) summary
      sd00039
      Location:50 → 86
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:47 → 146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_004937540.1 RNA Sequence

    2. XR_872718.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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