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    YEL1 Arf family guanine nucleotide exchange factor YEL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YEL1
    Official Full Name
    Arf family guanine nucleotide exchange factor YEL1
    Primary source
    SGD:S000000156
    Locus tag
    YBL060W
    See related
    AllianceGenome:SGD:S000000156; FungiDB:YBL060W; VEuPathDB:YBL060W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in actin cortical patch localization; positive regulation of phosphatidylinositol biosynthetic process; and protein localization. Located in cellular bud neck and cellular bud tip. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YEL1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (107932..109995)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Kip1p Neighboring gene Skt5p Neighboring gene Cmc2p Neighboring gene Iai11p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6. Gillingham AK, et al. PLoS One, 2007 Sep 5. PMID 17786213, Free PMC Article
    2. Afi1p functions as an Arf3p polarization-specific docking factor for development of polarity. Tsai PC, et al. J Biol Chem, 2008 Jun 13. PMID 18397879
    3. Arf3p GTPase is a key regulator of Bud2p activation for invasive growth in Saccharomyces cerevisiae. Hsu JW, et al. Mol Biol Cell, 2013 Aug. PMID 23783029, Free PMC Article
    4. Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain. Hsu JW, et al. Nat Commun, 2015 Jul 22. PMID 26198097, Free PMC Article
    5. Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis. Smaczynska-de Rooij II, et al. Traffic, 2008 Apr. PMID 18208507, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arf family guanine nucleotide exchange factor YEL1
    NP_009493.1
    • Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      107932..109995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178300.1 → NP_009493.1  TPA: Arf family guanine nucleotide exchange factor YEL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009493.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZKN8, C8Z3N7, D6VPT9, P34225
      UniProtKB/TrEMBL
      G2W8U8
      Conserved Domains (1) summary
      COG5307
      Location:1 → 687
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34225.1

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