Ddr2 discoidin domain receptor tyrosine kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddr2provided by RGD
Official Full Name: discoidin domain receptor tyrosine kinase 2provided by RGD
Primary source: RGD:619855
See related: EnsemblRapid:ENSRNOG00000002881 AllianceGenome:RGD:619855
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tyro10
Summary: Enables collagen binding activity. Involved in several processes, including negative regulation of programmed cell death; positive regulation of ERK1 and ERK2 cascade; and positive regulation of cell population proliferation. Located in apical plasma membrane. Used to study alcoholic liver cirrhosis. Biomarker of alcoholic liver cirrhosis. Human ortholog(s) of this gene implicated in bone disease (multiple) and gastrointestinal system cancer (multiple). Orthologous to human DDR2 (discoidin domain receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 164.7), Heart (RPKM 104.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (84726412..84851032, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (82193623..82318229, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (88311639..88436561, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metformin Attenuates Hyperglycaemia-Stimulated Pro-Fibrotic Gene Expression in Adventitial Fibroblasts via Inhibition of Discoidin Domain Receptor 2.
Title: Metformin Attenuates Hyperglycaemia-Stimulated Pro-Fibrotic Gene Expression in Adventitial Fibroblasts via Inhibition of Discoidin Domain Receptor 2.
Discoidin domain receptor 2 activation of p38 mitogen-activated protein kinase as an important pathway for osteonectin-regulating osteoblast mineralization.
Title: Discoidin domain receptor 2 activation of p38 mitogen-activated protein kinase as an important pathway for osteonectin-regulating osteoblast mineralization.
The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2.
Title: The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2.
DDR2 acted via integrin-beta1 to regulate alpha-smooth muscle actin (alpha-SMA) and collagen type I expression in Ang II-exposed cardiac fibroblasts.
Title: Collagen receptor cross-talk determines α-smooth muscle actin-dependent collagen gene expression in angiotensin II-stimulated cardiac fibroblasts.
Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression.
Title: Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression.
A reciprocal regulatory relationship between DDR2 and collagen, involving cross-talk between the GPCR and RTK pathways, is central to Angiotensin II-induced increase in collagen expression in cardiac fibroblasts.
Title: Molecular basis and functional significance of Angiotensin II-induced increase in Discoidin Domain Receptor 2 gene expression in cardiac fibroblasts.
regulation of DDRs by glucose
Title: Low stability and a conserved N-glycosylation site are associated with regulation of the discoidin domain receptor family by glucose via post-translational N-glycosylation.
DDR2 may have an important role in the pathogenesis of early-stage alcoholic liver disease. Silencing DDR2 may be effective in preventing early-stage alcoholic liver disease.
Title: RNA interference against discoidin domain receptor 2 ameliorates alcoholic liver disease in rats.
Data show that the expression of DDR2 is closely associated with collagens in the fibrotic liver tissues.
Title: Expression of discoidin domain receptors (DDR2) in alcoholic liver fibrosis in rats.
The expression of DDR2 in alcoholic liver fibrosis correlates closely with collagen deposition in the liver.
Title: [Expression of discoidin domain receptor 2 in different phases of alcoholic liver fibrosis in a rat model].

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

RH130509 (e-PCR)
- UniSTS:213793

AW495251 (e-PCR)
- UniSTS:178505

RH141613 (e-PCR)
- UniSTS:223607

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase collagen receptor activity	ISO Inferred from Sequence Orthology more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in biomineral tissue development	ISO Inferred from Sequence Orthology more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endochondral bone growth	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hydrogen peroxide-mediated programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hepatic stellate cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in regulation of tissue remodeling	ISO Inferred from Sequence Orthology more info
involved_in response to muscle stretch	IEP Inferred from Expression Pattern more info	PubMed
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: discoidin domain-containing receptor 2

Names: CD167b antigen; discoidin domain receptor family, member 2; neurotrophic tyrosine kinase, receptor-related 3; receptor protein-tyrosine kinase TKT; tyrosine-protein kinase TYRO 10

NP_113952.2

EC 2.7.10.1

XP_006250289.1

EC 2.7.10.1

XP_006250290.1

EC 2.7.10.1

XP_006250291.1

EC 2.7.10.1

XP_008767983.1

EC 2.7.10.1

XP_008767984.1

EC 2.7.10.1

XP_063128686.1

EC 2.7.10.1

XP_063128687.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031764.3 → NP_113952.2 discoidin domain-containing receptor 2 precursor

See identical proteins and their annotated locations for NP_113952.2

Status: PROVISIONAL

Source sequence(s)

BC161961

UniProtKB/TrEMBL

A0A8I6AIV9, A0A9K3Y730, B1WC09, F7EVN7

Related

ENSRNOP00000092781.2, ENSRNOT00000105822.2

Conserved Domains (2) summary

cd00057
Location:32 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:557 → 850

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

84726412..84851032 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769761.4 → XP_008767983.1 discoidin domain-containing receptor 2 isoform X1

See identical proteins and their annotated locations for XP_008767983.1

UniProtKB/TrEMBL

A0A8I6AIV9, A0A9K3Y730, B1WC09, F7EVN7

Conserved Domains (2) summary

cd00057
Location:32 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:557 → 850

PKc_like; Protein Kinases, catalytic domain
XM_006250229.5 → XP_006250291.1 discoidin domain-containing receptor 2 isoform X1

See identical proteins and their annotated locations for XP_006250291.1

UniProtKB/TrEMBL

A0A8I6AIV9, A0A9K3Y730, B1WC09, F7EVN7

Conserved Domains (2) summary

cd00057
Location:32 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:557 → 850

PKc_like; Protein Kinases, catalytic domain
XM_063272617.1 → XP_063128687.1 discoidin domain-containing receptor 2 isoform X1

UniProtKB/TrEMBL

A0A9K3Y730, B1WC09, F7EVN7
XM_006250227.5 → XP_006250289.1 discoidin domain-containing receptor 2 isoform X1

See identical proteins and their annotated locations for XP_006250289.1

UniProtKB/TrEMBL

A0A8I6AIV9, A0A9K3Y730, B1WC09, F7EVN7

Conserved Domains (2) summary

cd00057
Location:32 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:557 → 850

PKc_like; Protein Kinases, catalytic domain
XM_006250228.5 → XP_006250290.1 discoidin domain-containing receptor 2 isoform X1

See identical proteins and their annotated locations for XP_006250290.1

UniProtKB/TrEMBL

A0A8I6AIV9, A0A9K3Y730, B1WC09, F7EVN7

Conserved Domains (2) summary

cd00057
Location:32 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:557 → 850

PKc_like; Protein Kinases, catalytic domain
XM_008769762.3 → XP_008767984.1 discoidin domain-containing receptor 2 isoform X1

See identical proteins and their annotated locations for XP_008767984.1

UniProtKB/TrEMBL

A0A8I6AIV9, A0A9K3Y730, B1WC09, F7EVN7

Conserved Domains (2) summary

cd00057
Location:32 → 184

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:557 → 850

PKc_like; Protein Kinases, catalytic domain
XM_063272616.1 → XP_063128686.1 discoidin domain-containing receptor 2 isoform X1

UniProtKB/TrEMBL

A0A9K3Y730, B1WC09, F7EVN7