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    MIC19 Mic19p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850563, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MIC19
    Official Full Name
    Mic19p
    Primary source
    SGD:S000001907
    Locus tag
    YFR011C
    See related
    AllianceGenome:SGD:S000001907; FungiDB:YFR011C; VEuPathDB:YFR011C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AIM13; MCS19
    Summary
    Involved in cristae formation. Located in mitochondrial crista junction. Part of MICOS complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MIC19 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (166746..167258, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene putative AAA family ATPase GCN20 Neighboring gene ubiquitin-specific protease UBP6 Neighboring gene tRNA-Tyr Neighboring gene Dcv1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Oxidation Status of Mic19 Regulates MICOS Assembly. Sakowska P, et al. Mol Cell Biol, 2015 Dec. PMID 26416881, Free PMC Article
    2. Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System. Zerbes RM, et al. J Mol Biol, 2016 Apr 24. PMID 26968360
    3. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. Harner ME, et al. Elife, 2014 Jan 1. PMID 24714493, Free PMC Article
    4. Myristoyl group-aided protein import into the mitochondrial intermembrane space. Ueda E, et al. Sci Rep, 2019 Feb 4. PMID 30718713, Free PMC Article
    5. The mitochondrial contact site complex, a determinant of mitochondrial architecture. Harner M, et al. EMBO J, 2011 Oct 18. PMID 22009199, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in mitochondrial crista junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mic19p
    NP_116666.1
    • Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic19p is peripheral to the inner membrane and may connect Mic60p with the Mic10p-Mic12p-Mic27p subcomplex; both yeast and human Mic19p become oxidized, and oxidation may regulate MICOS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      166746..167258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179976.1 → NP_116666.1  TPA: Mic19p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116666.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTP1, P43594
      UniProtKB/TrEMBL
      A7A249, B3LUL9, B5VI37, C7GYB7, C8Z7U6, G2WDF0, N1PA27
      Conserved Domains (1) summary
      pfam07956
      Location:18 → 168
      DUF1690; Protein of Unknown function (DUF1690)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43594.1

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