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    Churc1 churchill domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299154, updated on 9-Dec-2024

    Summary

    Official Symbol
    Churc1provided by RGD
    Official Full Name
    churchill domain containing 1provided by RGD
    Primary source
    RGD:1305116
    See related
    EnsemblRapid:ENSRNOG00000007660 AllianceGenome:RGD:1305116
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein farnesyltransferase activity and zinc ion binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be part of microtubule associated complex and protein farnesyltransferase complex. Orthologous to human CHURC1 (churchill domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 469.6), Heart (RPKM 421.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Churc1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (101203778..101218364)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95464488..95485208)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99817439..99831574)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene spectrin, beta, erythrocytic Neighboring gene uncharacterized LOC134479402 Neighboring gene U6 spliceosomal RNA Neighboring gene glutathione peroxidase 2 Neighboring gene RAB15, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein farnesyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prenylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of microtubule associated complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein farnesyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106741.2NP_001100211.1  protein Churchill

      See identical proteins and their annotated locations for NP_001100211.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168770
      UniProtKB/TrEMBL
      A0A8I5ZP53, B5DER2, F7FBS9
      Related
      ENSRNOP00000009620.5, ENSRNOT00000009621.9
      Conserved Domains (1) summary
      pfam06573
      Location:1111
      Churchill; Churchill protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      101203778..101218364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112015.2XP_038967943.1  protein Churchill isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKJ2
      Related
      ENSRNOP00000103362.1, ENSRNOT00000150896.1
      Conserved Domains (1) summary
      pfam06573
      Location:160
      Churchill; Churchill protein