Npr3 natriuretic peptide receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npr3provided by RGD
Official Full Name: natriuretic peptide receptor 3provided by RGD
Primary source: RGD:3196
See related: EnsemblRapid:ENSRNOG00000019184 AllianceGenome:RGD:3196
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NPRC; ANP-CR
Summary: Enables identical protein binding activity; peptide hormone binding activity; and peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; and positive regulation of nitric-oxide synthase activity. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 153.4), Lung (RPKM 134.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (62592557..62660497, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (60865483..60933432, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (61883946..61950291, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA NONRATT014888.2 contributes to cancer-induced bone pain through downregulation of natriuretic peptide receptor 3 in rats.
Title: LncRNA NONRATT014888.2 contributes to cancer-induced bone pain through downregulation of natriuretic peptide receptor 3 in rats.
Downregulation of natriuretic peptide receptor-C in vascular smooth muscle cells from spontaneously hypertensive rats contributes to vascular remodeling.
Title: Downregulation of natriuretic peptide receptor-C in vascular smooth muscle cells from spontaneously hypertensive rats contributes to vascular remodeling.
[Changes of guanylate cyclase C in colon tissues of rats with intestinal injury associated with severe acute pancreatitis].
Title: [Changes of guanylate cyclase C in colon tissues of rats with intestinal injury associated with severe acute pancreatitis].
These results indicate that C-ANP4-23, via the activation of NPR-C, attenuates Ang II-induced enhanced nitroxidative stress, overexpression of Gialpha proteins, increased activation of the p38/JNK/ERK 1,2 signaling pathways.
Title: Natriuretic peptide receptor-C activation attenuates angiotensin II-induced enhanced oxidative stress and hyperproliferation of aortic vascular smooth muscle cells.
NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-alpha, which are regulators of apoptosis.
Title: NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-α.
down-regulation of Npr3 gene improves the circulatory levels of ANP and antioxidant system and there by attenuates the beta-adrenoceptor over-activation mediated cardiac hypertrophic growth
Title: Transient silencing of Npr3 gene expression improved the circulatory levels of atrial natriuretic peptides and attenuated β-adrenoceptor activation- induced cardiac hypertrophic growth in experimental rats.
Results from this study point to a role for miR-100 in the regulation of NPR3 expression, and suggest a possible therapeutic target for modulation of NP bioactivity in heart disease.
Title: Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100.
the increased expression of NPR-C (r=-0.943 and -0.837 for mRNA and protein respectively, p<0.05) and NEP (r=-0.687 and -0.823 for mRNA and protein respectively, p<0.05) were accompanied by a signi fi cant decline in CNP.
Title: Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy.
These results indicate that NPR-C activation by C-ANP4-23 attenuates the enhanced levels of cell cycle proteins through the inhibition of enhanced expression of Gialpha proteins
Title: Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling.
knockdown of NPR-A up-regulates the expression of NPR-C, Gialpha proteins, and NPR-C-linked adenylyl cyclase signalling and suggests a cross-talk between NPR-A and NPR-C.
Title: Knockdown of natriuretic peptide receptor-A enhances receptor C expression and signalling in vascular smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (31)

General gene information

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Markers

PMC17879P1 (e-PCR)
- UniSTS:271659

RH130055 (e-PCR)
- UniSTS:213343

Npr3 (e-PCR), detects polymorphism
- UniSTS:526956

PMC22098P1 (e-PCR)
- UniSTS:272097

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride ion binding	IEA Inferred from Electronic Annotation more info
enables chloride ion binding	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables natriuretic peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables natriuretic peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables natriuretic peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables natriuretic peptide receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables natriuretic peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables natriuretic peptide receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	IEA Inferred from Electronic Annotation more info
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast proliferation	IEA Inferred from Electronic Annotation more info
involved_in osteoclast proliferation	ISO Inferred from Sequence Orthology more info
involved_in osteoclast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric-oxide synthase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of pancreatic juice secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of urine volume	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urine volume	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of osteoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal system development	IEA Inferred from Electronic Annotation more info
involved_in skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: atrial natriuretic peptide receptor 3

Names: ANP-C; ANPR-C; ANPRC; Atrial natriuretic peptide clearence receptor 3; NPR-C; atrial natriuretic peptide C-type receptor; atrial natriuretic peptide clearance receptor; atrial natriuretic peptide receptor type C; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012868.1 → NP_037000.1 atrial natriuretic peptide receptor 3 precursor

See identical proteins and their annotated locations for NP_037000.1

Status: PROVISIONAL

Source sequence(s)

L27339

UniProtKB/Swiss-Prot

P41740, Q64156

UniProtKB/TrEMBL

A6KJR1

Conserved Domains (2) summary

cd06386
Location:49 → 440

PBP1_NPR_C_like; Ligand-binding domain of type C natriuretic peptide receptor

cl25995
Location:466 → 501

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

62592557..62660497 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101782.2 → XP_038957710.1 atrial natriuretic peptide receptor 3 isoform X2

UniProtKB/TrEMBL

A6KJR3

Conserved Domains (2) summary

cd12841
Location:217 → 248

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

cl10011
Location:1 → 187

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_006232045.5 → XP_006232107.2 atrial natriuretic peptide receptor 3 isoform X1

UniProtKB/TrEMBL

A0A8L2QFC4

Related

ENSRNOP00000025966.5, ENSRNOT00000025966.7