Gfra3 glial cell line derived neurotrophic factor family receptor alpha 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gfra3provided by MGI
Official Full Name: glial cell line derived neurotrophic factor family receptor alpha 3provided by MGI
Primary source: MGI:MGI:1201403
See related: Ensembl:ENSMUSG00000024366 AllianceGenome:MGI:1201403
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GFRalpha3
Summary: This gene encodes a cell surface glycoprotein and member of the glial cell line-derived neurotrophic receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein mediates binding of the ligand artemin to the ret receptor tyrosine kinase, and this interaction may regulate thermal pain and axon regeneration. Homozygous knockout mice for this gene exhibit impaired proliferation of cultured neuroblasts and impaired development of the superior cervical ganglion. [provided by RefSeq, Aug 2015]
Expression: Broad expression in bladder adult (RPKM 4.1), colon adult (RPKM 3.0) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 18.69 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (34822951..34853440, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (34689898..34720387, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRalpha3.
Title: Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3.
The authors have identified and characterized the expression of GFRalpha3 in nerve terminal endings and non-neuronal cells in the bone marrow.
Title: A population of nonneuronal GFRα3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells.
GFRa3 is expressed at the surface of a subset of Ngn3-positive endocrine progenitors as well as of embryonic alpha- and beta-cells in the mouse pancreas.
Title: Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas.
cold allodynia is mediated exclusively by a single molecular pathway, suggesting that artemin-GFRalpha3 signaling can be targeted to selectively treat cold pain.
Title: Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFRα3.
We found that artemin, the specific GFRalpha3 ligand that evokes heat hyperalgesia, robustly sensitized cold responses in a TRPM8-dependent manner in mice.
Title: Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain.
Suggest that enhanced GFRalpha3 signaling in visceral afferents may contribute to development of colorectal hypersensitivity.
Title: Modulation of visceral hypersensitivity by glial cell line-derived neurotrophic factor family receptor α-3 in colorectal afferents.
GFRalpha3, the receptor for artemin, is increased following axotomy and regeneration in heat-sensitive C-fibers.
Title: Enhanced artemin/GFRα3 levels regulate mechanically insensitive, heat-sensitive C-fiber recruitment after axotomy and regeneration.
Data report an autocrine/paracrine role of the artemin-GFRA3 signaling system in regulating early embryonic development and apoptosis.
Title: Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y15110 (e-PCR)
- UniSTS:163600

Gfra3 (e-PCR), detects polymorphism
- UniSTS:527071

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables axon guidance receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables coreceptor activity	TAS Traceable Author Statement more info	PubMed
enables glial cell-derived neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables glial cell-derived neurotrophic factor receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sympathetic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GDNF family receptor alpha-3

Names: GDNFR-alpha-3; GFR alpha-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010280.4 → NP_034410.3 GDNF family receptor alpha-3 preproprotein

Status: REVIEWED

Source sequence(s)

AC145591, AK046542

Consensus CDS

CCDS29133.1

UniProtKB/Swiss-Prot

O35118, O35325, O55243, Q6NZC2, Q8C8L9

UniProtKB/TrEMBL

Q9R2D0

Related

ENSMUSP00000025224.8, ENSMUST00000025224.9

Conserved Domains (2) summary

smart00907
Location:41 → 118

GDNF; GDNF/GAS1 domain

pfam02351
Location:245 → 337

GDNF; GDNF/GAS1 domain