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    Tmem161a transmembrane protein 161A [ Mus musculus (house mouse) ]

    Gene ID: 234371, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem161aprovided by MGI
    Official Full Name
    transmembrane protein 161Aprovided by MGI
    Primary source
    MGI:MGI:2384577
    See related
    Ensembl:ENSMUSG00000002342 AllianceGenome:MGI:2384577
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in several processes, including cellular response to UV; regulation of cellular response to stress; and response to retinoic acid. Predicted to be located in membrane. Is expressed in heart ventricle. Orthologous to human TMEM161A (transmembrane protein 161A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 47.3), ovary adult (RPKM 34.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem161a in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70624979..70636331)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70172329..70183681)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1102 Neighboring gene STARR-seq mESC enhancer starr_21765 Neighboring gene BLOC-1 related complex subunit 8 Neighboring gene myocyte enhancer factor 2B like Neighboring gene STARR-positive B cell enhancer ABC_E3776 Neighboring gene myocyte enhancer factor 2B Neighboring gene STARR-positive B cell enhancer ABC_E10504 Neighboring gene solute carrier family 25, member 42 Neighboring gene STARR-positive B cell enhancer ABC_E1103 Neighboring gene armadillo repeat containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E8239 Neighboring gene SURP and G patch domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway. Nagai T, et al. Sci Rep, 2023 Sep 5. PMID 37670024, Free PMC Article
    2. SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. Xie X, et al. FASEB J, 2023 May. PMID 37039821
    3. Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Kurogi S, et al. Sci Rep, 2017 Jan 20. PMID 28106071, Free PMC Article
    4. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway.
      Title: Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29210

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 161A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293797.2 → NP_001280726.1  transmembrane protein 161A isoform 2

      See identical proteins and their annotated locations for NP_001280726.1

      Status: VALIDATED

      Source sequence(s)
      AC124327
      Consensus CDS
      CCDS80890.1
      UniProtKB/Swiss-Prot
      Q8VCA6
      Related
      ENSMUSP00000138499.2, ENSMUST00000182980.8
      Conserved Domains (1) summary
      pfam10268
      Location:2 → 325
      Tmemb_161AB; Predicted transmembrane protein 161AB

    2. NM_001426658.1 → NP_001413587.1  transmembrane protein 161A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124327

    3. NM_001426659.1 → NP_001413588.1  transmembrane protein 161A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124327

    4. NM_001426660.1 → NP_001413589.1  transmembrane protein 161A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124327

    5. NM_001426661.1 → NP_001413590.1  transmembrane protein 161A isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124327

    6. NM_145597.5 → NP_663572.1  transmembrane protein 161A isoform 1 precursor

      See identical proteins and their annotated locations for NP_663572.1

      Status: VALIDATED

      Source sequence(s)
      AC124327
      Consensus CDS
      CCDS40369.1
      UniProtKB/Swiss-Prot
      Q8BNL7, Q8BSL1, Q8C2I8, Q8VCA6
      UniProtKB/TrEMBL
      F6UNW2
      Related
      ENSMUSP00000002413.9, ENSMUST00000002413.15
      Conserved Domains (1) summary
      pfam10268
      Location:2 → 477
      Tmemb_161AB; Predicted transmembrane protein 161AB

    RNA

    1. NR_122028.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124327

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70624979..70636331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242296.2 → XP_011240598.1  transmembrane protein 161A isoform X4

      Conserved Domains (1) summary
      pfam10268
      Location:33 → 311
      Tmemb_161AB; Predicted transmembrane protein 161AB
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCA6.1 GenPept UniProtKB/Swiss-Prot:Q8VCA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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