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    Hs3st3b1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 [ Mus musculus (house mouse) ]

    Gene ID: 54710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hs3st3b1provided by MGI
    Official Full Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1provided by MGI
    Primary source
    MGI:MGI:1333853
    See related
    Ensembl:ENSMUSG00000070407 AllianceGenome:MGI:1333853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3Ost3b; 3OST3B1; Hs3st3b; 3-OST-3B; m3-OST-3B
    Summary
    Enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in branching involved in ureteric bud morphogenesis and heparan sulfate proteoglycan biosynthetic process. Acts upstream of or within protein sulfation. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and respiratory system. Orthologous to human HS3ST3B1 (heparan sulfate-glucosamine 3-sulfotransferase 3B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in stomach adult (RPKM 31.6), liver adult (RPKM 20.3) and 18 other tissues See more
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    Genomic context

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    See Hs3st3b1 in Genome Data Viewer
    Location:
    11 B3; 11 39.47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (63775519..63813110, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (63884693..63922284, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protease (prosome, macropain) 26S subunit, ATPase 1 pseudogene Neighboring gene high mobility group box 1, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_29739 Neighboring gene STARR-seq mESC enhancer starr_29740 Neighboring gene STARR-positive B cell enhancer ABC_E1420 Neighboring gene STARR-seq mESC enhancer starr_29745 Neighboring gene STARR-seq mESC enhancer starr_29746 Neighboring gene RIKEN cDNA 9630013K17 gene Neighboring gene predicted gene, 30060 Neighboring gene heme A:farnesyltransferase cytochrome c oxidase assembly factor 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of the Expression of Heparan Sulfate 3-O-Sulfotransferase 3B (HS3ST3B) by Inflammatory Stimuli in Human Monocytes. Sikora AS, et al. J Cell Biochem, 2016 Jul. PMID 26575945
    2. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Shukla D, et al. Cell, 1999 Oct 1. PMID 10520990
    3. Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney. Rutledge EA, et al. Dev Dyn, 2020 Jun. PMID 32017326, Free PMC Article
    4. Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain. Yabe T, et al. Glycobiology, 2005 Oct. PMID 15944372
    5. FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Chen Z, et al. Development, 2014 Jul. PMID 24924191, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.
      Title: Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.
    2. findings indicate that HS3ST3B1 gene behaves as a primary response gene, suggesting that it may play an important role in making 3-O-sulfated HS with specific functions in the regulation of inflammatory and immune responses.
      Title: Regulation of the Expression of Heparan Sulfate 3-O-Sulfotransferase 3B (HS3ST3B) by Inflammatory Stimuli in Human Monocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 3B1
    Names
    D-glycosaminyl 3-O-sulfotransferase-3B
    heparan sulfate 3-O-sulfotransferase 3B1
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1
    NP_061275.2
    XP_030102020.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018805.2 → NP_061275.2  heparan sulfate glucosamine 3-O-sulfotransferase 3B1

      See identical proteins and their annotated locations for NP_061275.2

      Status: VALIDATED

      Source sequence(s)
      AK085242, AL603889
      Consensus CDS
      CCDS24838.1
      UniProtKB/Swiss-Prot
      Q5NCR0, Q9QZS6
      UniProtKB/TrEMBL
      Q3TA92
      Related
      ENSMUSP00000091647.4, ENSMUST00000094103.4
      Conserved Domains (1) summary
      pfam00685
      Location:137 → 374
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      63775519..63813110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246160.1 → XP_030102020.1  heparan sulfate glucosamine 3-O-sulfotransferase 3B1 isoform X1

      Conserved Domains (1) summary
      pfam00685
      Location:1 → 187
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZS6.2 GenPept UniProtKB/Swiss-Prot:Q9QZS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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