Atat1 alpha tubulin acetyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atat1provided by MGI
Official Full Name: alpha tubulin acetyltransferase 1provided by MGI
Primary source: MGI:MGI:1913869
See related: Ensembl:ENSMUSG00000024426 AllianceGenome:MGI:1913869
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TAT; Mec17; MEC-17; 0610011P08Rik; 2610008K08Rik; 2610110G12Rik; 3110080J08Rik
Summary: Enables tubulin N-acetyltransferase activity. Involved in microtubule cytoskeleton organization; response to mechanical stimulus; and response to pain. Acts upstream of or within several processes, including alpha-tubulin acetylation; dentate gyrus development; and positive regulation of NLRP3 inflammasome complex assembly. Located in microtubule bundle. Is active in membrane. Is expressed in several structures, including adrenal gland; central nervous system; gut; male reproductive gland or organ; and neural retina. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 75.6), CNS E14 (RPKM 67.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.75 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (36208487..36220971, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35897595..35910086, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice.
Title: Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice.
PAK1 Regulates MEC-17 Acetyltransferase Activity and Microtubule Acetylation during Proplatelet Extension.
Title: PAK1 Regulates MEC-17 Acetyltransferase Activity and Microtubule Acetylation during Proplatelet Extension.
The Major Capsid Protein, VP1, of the Mouse Polyomavirus Stimulates the Activity of Tubulin Acetyltransferase 1 by Microtubule Stabilization.
Title: The Major Capsid Protein, VP1, of the Mouse Polyomavirus Stimulates the Activity of Tubulin Acetyltransferase 1 by Microtubule Stabilization.
p27(Kip1) stabilizes the alpha-tubulin acetyltransferase 1, thereby promoting the acetylation of microtubules, a post-translational modification required for proper axonal transport.
Title: p27(Kip1) Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability.
ATAT1 found in regulating mouse forebrain development and governing tubulin hyperacetylation during stress responses, but also suggests the existence of an additional alpha-tubulin acetyltransferase.
Title: ATAT1 regulates forebrain development and stress-induced tubulin hyperacetylation.
TAK1 directly interacts with and phosphorylates alphaTAT1 at Ser237 to critically enhance its catalytic activity.
Title: TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth.
Atat1 knockdown resulted in a significant increase in the expression of ACTH-producing genes and decreased the dexamethasone-induced nuclear translocation of glucocorticoid receptor accompanied with a reduction in alpha-tubulin acetylation.
Title: ATAT1 is essential for regulation of homeostasis-retaining cellular responses in corticotrophs along hypothalamic-pituitary-adrenal axis.
Here the authors demonstrate that mice lacking the alpha-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical stimuli.
Title: Acetylated tubulin is essential for touch sensation in mice.
alphaTAT1 has a conserved function as the major alpha-tubulin acetyltransferase in ciliated organisms and has an important role in regulating subcellular specialization of subsets of microtubules.
Title: αTAT1 is the major α-tubulin acetyltransferase in mice.
Data indicate that alpha-tubulin acetyltransferase 1 Atat1 is not required for survival and development but may regulate more advanced functions.
Title: Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortion.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO Inferred from Sequence Orthology more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables tubulin N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of NLRP3 inflammasome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within alpha-tubulin acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within alpha-tubulin acetylation	ISO Inferred from Sequence Orthology more info
involved_in alpha-tubulin acetylation	ISO Inferred from Sequence Orthology more info
involved_in alpha-tubulin acetylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dentate gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of NLRP3 inflammasome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule bundle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-tubulin N-acetyltransferase 1

Names: acetyltransferase mec-17 homolog; alpha-TAT; alpha-TAT1

NP_001136216.1

EC 2.3.1.108

NP_001136217.1

EC 2.3.1.108

NP_001334307.1

EC 2.3.1.108

NP_001344794.1

EC 2.3.1.108

NP_082752.3

EC 2.3.1.108

XP_036016697.1

EC 2.3.1.108

XP_036016698.1

EC 2.3.1.108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142744.1 → NP_001136216.1 alpha-tubulin N-acetyltransferase 1 isoform 1

See identical proteins and their annotated locations for NP_001136216.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). It should be noted that this variant contains an overlapping upstream ORF that may interfere with the translation of the annotated CDS.

Source sequence(s)

AK011750, AK133694, BB857404, BQ748472

Consensus CDS

CCDS50096.1

UniProtKB/Swiss-Prot

B8JJ75, B8JJ77, Q3UZR9, Q8BM67, Q8C1D1, Q8K2M7, Q8K341

Related

ENSMUSP00000056383.6, ENSMUST00000061052.12

Conserved Domains (1) summary

pfam05301
Location:79 → 190

Mec-17; Touch receptor neuron protein Mec-17
NM_001142745.1 → NP_001136217.1 alpha-tubulin N-acetyltransferase 1 isoform 2

See identical proteins and their annotated locations for NP_001136217.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a few of 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1. It should be noted that this variant contains an overlapping upstream ORF that may interfere with the translation of the annotated CDS.

Source sequence(s)

AK133694, BB857404, CX223131

Consensus CDS

CCDS50097.1

UniProtKB/Swiss-Prot

Q8K341

Related

ENSMUSP00000115004.2, ENSMUST00000141662.8

Conserved Domains (2) summary

pfam05301
Location:10 → 190

Acetyltransf_16; GNAT acetyltransferase, Mec-17

pfam08580
Location:143 → 324

KAR9; Yeast cortical protein KAR9
NM_001347378.1 → NP_001334307.1 alpha-tubulin N-acetyltransferase 1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

BQ748472, CR974451

Consensus CDS

CCDS84305.1

UniProtKB/Swiss-Prot

Q8K341

Related

ENSMUSP00000076703.7, ENSMUST00000077494.13
NM_001357865.1 → NP_001344794.1 alpha-tubulin N-acetyltransferase 1 isoform 5

Status: VALIDATED

Source sequence(s)

AK028297, BB857404, BC030669, BQ748472

Consensus CDS

CCDS89088.1

Related

ENSMUSP00000122715.2, ENSMUST00000149277.8

Conserved Domains (2) summary

PHA03378
Location:195 → 305

PHA03378; EBNA-3B; Provisional

pfam05301
Location:10 → 190

Acetyltransf_16; GNAT acetyltransferase, Mec-17
NM_028476.4 → NP_082752.3 alpha-tubulin N-acetyltransferase 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an internal in-frame coding exon and a few of 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment and has a shorter and different C-terminus, as compared to isoform 1. It should be noted that this variant contains an overlapping upstream ORF that may interfere with the translation of the annotated CDS.

Source sequence(s)

AK049682, BB857404, CX223131

Consensus CDS

CCDS28711.1

UniProtKB/Swiss-Prot

Q8K341

Related

ENSMUSP00000053853.7, ENSMUST00000056034.13

Conserved Domains (1) summary

pfam05301
Location:79 → 190

Mec-17; Touch receptor neuron protein Mec-17

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

36208487..36220971 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160804.1 → XP_036016697.1 alpha-tubulin N-acetyltransferase 1 isoform X1

Conserved Domains (2) summary

PHA03378
Location:195 → 305

PHA03378; EBNA-3B; Provisional

pfam05301
Location:10 → 190

Acetyltransf_16; GNAT acetyltransferase, Mec-17
XM_036160805.1 → XP_036016698.1 alpha-tubulin N-acetyltransferase 1 isoform X2

Conserved Domains (1) summary

pfam05301
Location:10 → 190

Acetyltransf_16; GNAT acetyltransferase, Mec-17