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    Hs3st3a1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 [ Mus musculus (house mouse) ]

    Gene ID: 15478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hs3st3a1provided by MGI
    Official Full Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1provided by MGI
    Primary source
    MGI:MGI:1333861
    See related
    Ensembl:ENSMUSG00000047759 AllianceGenome:MGI:1333861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3Ost3a; Hs3st3a
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in branching involved in ureteric bud morphogenesis and heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including bone; central nervous system; genitourinary system; nose; and respiratory system. Orthologous to human HS3ST3A1 (heparan sulfate-glucosamine 3-sulfotransferase 3A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in stomach adult (RPKM 9.7), genital fat pad adult (RPKM 7.3) and 21 other tissues See more
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    Genomic context

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    See Hs3st3a1 in Genome Data Viewer
    Location:
    11 B3; 11 40.24 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (64326158..64413667)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (64435332..64522835)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29755 Neighboring gene predicted gene, 53711 Neighboring gene predicted gene, 53712 Neighboring gene STARR-seq mESC enhancer starr_29756 Neighboring gene STARR-seq mESC enhancer starr_29758 Neighboring gene RIKEN cDNA F930015N05 gene Neighboring gene STARR-seq mESC enhancer starr_29759 Neighboring gene predicted gene, 30305 Neighboring gene predicted gene 12292 Neighboring gene predicted gene, 40025

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. 3-O sulfation of syndecan-1 mediated by the sulfotransferase HS3ST3a1 enhances myeloma aggressiveness. Baert L, et al. Matrix Biol, 2023 Jun. PMID 37201729
    2. Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney. Rutledge EA, et al. Dev Dyn, 2020 Jun. PMID 32017326, Free PMC Article
    3. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. Liu J, et al. J Biol Chem, 1999 Feb 19. PMID 9988768
    4. FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Chen Z, et al. Development, 2014 Jul. PMID 24924191, Free PMC Article
    5. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. Shworak NW, et al. J Biol Chem, 1999 Feb 19. PMID 9988767

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 3-O sulfation of syndecan-1 mediated by the sulfotransferase HS3ST3a1 enhances myeloma aggressiveness.
      Title: 3-O sulfation of syndecan-1 mediated by the sulfotransferase HS3ST3a1 enhances myeloma aggressiveness.
    2. Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.
      Title: Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 3A1
    Names
    heparan sulfate 3-O-sulfotransferase 3A1
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
    NP_849201.1
    XP_030101453.1
    XP_036012238.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178870.5 → NP_849201.1  heparan sulfate glucosamine 3-O-sulfotransferase 3A1

      See identical proteins and their annotated locations for NP_849201.1

      Status: VALIDATED

      Source sequence(s)
      AL646051, AL672141
      Consensus CDS
      CCDS24840.1
      UniProtKB/Swiss-Prot
      Q8BKN6
      UniProtKB/TrEMBL
      Q52KJ0
      Related
      ENSMUSP00000055930.6, ENSMUST00000058652.6
      Conserved Domains (1) summary
      pfam00685
      Location:139 → 376
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      64326158..64413667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245593.2 → XP_030101453.1  heparan sulfate glucosamine 3-O-sulfotransferase 3A1 isoform X1

      Conserved Domains (1) summary
      cl21551
      Location:139 → 191
      Sulfotransfer_3; Sulfotransferase family

    2. XM_036156345.1 → XP_036012238.1  heparan sulfate glucosamine 3-O-sulfotransferase 3A1 isoform X2

      Conserved Domains (1) summary
      pfam00685
      Location:27 → 187
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKN6.1 GenPept UniProtKB/Swiss-Prot:Q8BKN6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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