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    PIR1 beta-1,3-glucan linked protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIR1
    Official Full Name
    beta-1,3-glucan linked protein
    Primary source
    SGD:S000001647
    Locus tag
    YKL164C
    See related
    AllianceGenome:SGD:S000001647; FungiDB:YKL164C; VEuPathDB:YKL164C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CCW6
    Summary
    A structural constituent of cell wall. Involved in fungal-type cell wall organization and intracellular protein transport. Located in cellular bud scar and nuclear periphery. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PIR1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (141794..142819, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene mannose-ethanolamine phosphotransferase MCD4 Neighboring gene tRNA-Glu Neighboring gene beta-1,3-glucan linked protein Neighboring gene type II protein arginine methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Construction of a novel Pichia pastoris cell-surface display system based on the cell wall protein Pir1. Wang Q, et al. Curr Microbiol, 2008 Apr. PMID 18188644
    2. Pir1p mediates translocation of the yeast Apn1p endonuclease into the mitochondria to maintain genomic stability. Vongsamphanh R, et al. Mol Cell Biol, 2001 Mar. PMID 11238901, Free PMC Article
    3. The contribution of the O-glycosylated protein Pir2p/Hsp150 to the construction of the yeast cell wall in wild-type cells and beta 1,6-glucan-deficient mutants. Kapteyn JC, et al. Mol Microbiol, 1999 Mar. PMID 10209754
    4. Three yeast genes, PIR1, PIR2 and PIR3, containing internal tandem repeats, are related to each other, and PIR1 and PIR2 are required for tolerance to heat shock. Toh-e A, et al. Yeast, 1993 May. PMID 8322511
    5. ATPase activity of a yeast secretory glycoprotein allows ER exit during inactivation of COPII components Sec24p and Sec13p. Suntio T, et al. Yeast, 2011 Jun. PMID 21446055

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that bud scars contain proteins like Pir1p as internal components.
      Title: Comparison of cell wall localization among Pir family proteins and functional dissection of the region required for cell wall binding and bud scar recruitment of Pir1p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cell wall IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud scar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type cell wall IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-1,3-glucan linked protein
    NP_012757.1
    • O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      141794..142819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179730.1 → NP_012757.1  TPA: beta-1,3-glucan linked protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012757.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZZG0, D6VX35, Q03178
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03178.1

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