Cdc25c cell division cycle 25C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc25cprovided by MGI
Official Full Name: cell division cycle 25Cprovided by MGI
Primary source: MGI:MGI:88350
See related: Ensembl:ENSMUSG00000044201 AllianceGenome:MGI:88350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdc25
Summary: This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]
Expression: Biased expression in CNS E11.5 (RPKM 9.4), liver E14 (RPKM 5.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 18.71 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (34866046..34884644, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (34732993..34751564, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

oxidative stress-induced DNA damage of mouse zygotes triggers the cell cycle checkpoint, which results in G2/M cell cycle arrest, and that phospho-Cdc25B (Ser323), phospho-Cdc25C (Ser216), and phospho-Cdc2 (Tyr15) participate in activating the G2/M checkpoint.
Title: Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2.
The role of Cdc25c and Cdc25b in activating G2/M cell cycle checkpoint in zygote.
Title: Phospho-Cdc25 correlates with activating G2/M checkpoint in mouse zygotes fertilized with hydrogen peroxide-treated mouse sperm.
an asymmetrical distribution pattern for Cdc25c transcripts in 2-cell embryos.
Title: Differential expression of Axin1, Cdc25c and Cdkn2d mRNA in 2-cell stage mouse blastomeres.
CDC25A and CDC25B but not CDC25C compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells
Title: Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells.
PP2A:B56delta as a key upstream regulator of Cdk1 activity upon exit from mitosis
Title: Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.
A single cell cycle genes homology region controls transcription of the cdc25C gene and is able to cooperate with E2F or Sp1/3 sites
Title: A single cell cycle genes homology region (CHR) controls cell cycle-dependent transcription of the cdc25C phosphatase gene and is able to cooperate with E2F or Sp1/3 sites.
In Lzts1(-/-) mouse embryo fibroblasts (MEFs), Cdc25C degradation was increased during M phase, resulting in decreased Cdk1 activity.
Title: Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
Cdc25A, or possibly other phosphatases, is able to functionally compensate for the loss of Cdc25B and Cdc25C in mice
Title: Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases.
The present study was aimed to investigate the possibility that selenium (Se)-induced oxidative stress mediated alterations in Cdc25c and p21 may cause modulations in the CDC2/Cyclin B1 complex responsible for G2/M phase checkpoint in spermatogenesis.
Title: Inhibition of CDC2/Cyclin B1 in response to selenium-induced oxidative stress during spermatogenesis: potential role of Cdc25c and p21.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L16926 (e-PCR)
- UniSTS:163596

G42918 (e-PCR)
- UniSTS:94820

AU048852 (e-PCR)
- UniSTS:145302

PMC87049P1 (e-PCR)
- UniSTS:273573

NoName (e-PCR)
- UniSTS:237772

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables WW domain binding	IEA Inferred from Electronic Annotation more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: M-phase inducer phosphatase 3

Names: cell cycle phosphatase CDC25C; cell division cycle control protein 25C; dual specificity phosphatase Cdc25C

NP_033990.2

EC 3.1.3.48

XP_006525614.1

EC 3.1.3.48

XP_011245121.1

EC 3.1.3.48

XP_036016849.1

EC 3.1.3.48

XP_036016850.1

EC 3.1.3.48

XP_036016851.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009860.3 → NP_033990.2 M-phase inducer phosphatase 3

See identical proteins and their annotated locations for NP_033990.2

Status: REVIEWED

Source sequence(s)

AC145591, AK141737

Consensus CDS

CCDS37759.1

UniProtKB/Swiss-Prot

P48967, Q99KG6

UniProtKB/TrEMBL

Q3THG4, Q3UR74

Related

ENSMUSP00000055427.8, ENSMUST00000060710.9

Conserved Domains (1) summary

cd01530
Location:275 → 394

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

34866046..34884644 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160957.1 → XP_036016850.1 M-phase inducer phosphatase 3 isoform X3

Conserved Domains (1) summary

cd01530
Location:89 → 208

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
XM_006525551.4 → XP_006525614.1 M-phase inducer phosphatase 3 isoform X2

UniProtKB/TrEMBL

Q3THG4

Conserved Domains (1) summary

cd01530
Location:200 → 319

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
XM_036160956.1 → XP_036016849.1 M-phase inducer phosphatase 3 isoform X1

UniProtKB/Swiss-Prot

P48967, Q99KG6

UniProtKB/TrEMBL

Q3THG4, Q3UR74

Conserved Domains (1) summary

cd01530
Location:275 → 394

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
XM_011246819.2 → XP_011245121.1 M-phase inducer phosphatase 3 isoform X3

Conserved Domains (1) summary

cd01530
Location:89 → 208

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
XM_036160958.1 → XP_036016851.1 M-phase inducer phosphatase 3 isoform X3

Conserved Domains (1) summary

cd01530
Location:89 → 208

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...