FPR1 peptidylprolyl isomerase FPR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FPR1
Official Full Name: peptidylprolyl isomerase FPR1
Primary source: SGD:S000005079
Locus tag: YNL135C
See related: AllianceGenome:SGD:S000005079; FungiDB:YNL135C; VEuPathDB:YNL135C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FKB1; RBP1
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; macrolide binding activity; and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including RNA metabolic process; regulation of chaperone-mediated protein folding; and regulation of homoserine biosynthetic process. Located in mitochondrion and nucleus. Is active in cytoplasm. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1A (FKBP prolyl isomerase 1A); FKBP1B (FKBP prolyl isomerase 1B); and FKBP1C (FKBP prolyl isomerase family member 1C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FPR1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (371882..372226, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FPR1 is essential for rapamycin-induced lifespan extension in Saccharomyces cerevisiae.
Title: FPR1 is essential for rapamycin-induced lifespan extension in Saccharomyces cerevisiae.
Saccharomyces cerevisiae Fpr1 functions as a chaperone to inhibit protein aggregation.
Title: Saccharomyces cerevisiae Fpr1 functions as a chaperone to inhibit protein aggregation.
Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast.
Title: Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast.
Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.
Title: Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.
mutation or inhibition of FKBP12 dysregulates the homoserine synthetic pathway by perturbing aspartokinase feedback inhibition by threonine
Title: FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables macrolide binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein folding chaperone	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nonfunctional rRNA decay	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of homoserine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: peptidylprolyl isomerase FPR1

NP_014264.1

EC 5.2.1.8

Peptidyl-prolyl cis-trans isomerase (PPIase); binds to FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; associates with promoters of ribosomal protein genes; acts as chaperone to prevent protein aggregation; N-terminally propionylated in vivo; mutation is functionally complemented by human FKBP1A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

371882..372226 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182973.1 → NP_014264.1 TPA: peptidylprolyl isomerase FPR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014264.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W147, P20081

UniProtKB/TrEMBL

A6ZRU8, B3LNZ2, C7GKB2, C8ZG95, G2WLX1, N1NZB8

Conserved Domains (1) summary

COG0545
Location:1 → 114

FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]