Iws1 IWS1, SUPT6 interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iws1provided by MGI
Official Full Name: IWS1, SUPT6 interacting proteinprovided by MGI
Primary source: MGI:MGI:1920723
See related: Ensembl:ENSMUSG00000024384 AllianceGenome:MGI:1920723
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3000008H23; 1700069O15Rik
Summary: Predicted to be involved in several processes, including poly(A)+ mRNA export from nucleus; regulation of mRNA export from nucleus; and regulation of mRNA processing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human IWS1 (interacts with SUPT6H, CTD assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.3), whole brain E14.5 (RPKM 5.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 17.92 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (32200377..32237384)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (32067326..32104331)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.
Title: Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_21654-21655:1033408890:1 (e-PCR)
- UniSTS:268596

AW214353 (e-PCR)
- UniSTS:181103

RH136617 (e-PCR)
- UniSTS:210597

NoName (e-PCR)
- UniSTS:237757

BE118002 (e-PCR)
- UniSTS:248779

NoName (e-PCR)
- UniSTS:237792

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription elongation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein IWS1 homolog

Names: IWS1 homolog; IWS1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173441.4 → NP_775617.1 protein IWS1 homolog

See identical proteins and their annotated locations for NP_775617.1

Status: VALIDATED

Source sequence(s)

AC127347

Consensus CDS

CCDS29115.1

UniProtKB/Swiss-Prot

Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q8C1D8, Q9D9H4

Related

ENSMUSP00000025243.4, ENSMUST00000025243.5

Conserved Domains (2) summary

PHA02664
Location:206 → 317

PHA02664; hypothetical protein; Provisional

cl00146
Location:475 → 739

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

32200377..32237384

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526292.5 → XP_006526355.1 protein IWS1 homolog isoform X2

Conserved Domains (2) summary

COG5271
Location:3 → 464

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cl00146
Location:474 → 738

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
XM_006526291.5 → XP_006526354.1 protein IWS1 homolog isoform X1

UniProtKB/TrEMBL

A0A1D5RLV0

Related

ENSMUSP00000148514.2, ENSMUST00000212675.2

Conserved Domains (2) summary

COG5271
Location:18 → 462

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cl00146
Location:475 → 724

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme