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    hfq RNA-binding protein Hfq [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948689, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hfq
    Official Full Name
    RNA-binding protein Hfq
    Primary source
    ECOCYC:EG10438
    Locus tag
    b4172
    See related
    ASAP:ABE-0013659
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4168
    Summary
    The C-terminal of Hfq is not necessary for hexamerization. [More information is available at EcoGene: EG10438]. Hfq is an RNA-binding protein that stimulates RNA-RNA pairing and affects many cellular processes, similar to mammalian Sm/Sm-like proteins . [More information is available at EcoCyc: EG10438].
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    Genomic context

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    Sequence:
    NC_000913.3 (4400288..4400596)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylmuramoyl-L-alanine amidase B Neighboring gene DNA mismatch repair protein MutL Neighboring gene tRNA dimethylallyltransferase Neighboring gene ribosome rescue factor HflX Neighboring gene regulator of FtsH protease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of Escherichia coli Hfq bound to polyriboadenylate RNA. Link TM, et al. Proc Natl Acad Sci U S A, 2009 Nov 17. PMID 19889981, Free PMC Article
    2. Identifying Hfq-binding small RNA targets in Escherichia coli. Zhang Y, et al. Biochem Biophys Res Commun, 2006 May 12. PMID 16574072
    3. Hfq structure, function and ligand binding. Brennan RG, et al. Curr Opin Microbiol, 2007 Apr. PMID 17395525
    4. Identification of bacterial small non-coding RNAs: experimental approaches. Altuvia S. Curr Opin Microbiol, 2007 Jun. PMID 17553733
    5. Sm-like protein Hfq: location of the ATP-binding site and the effect of ATP on Hfq-- RNA complexes. Arluison V, et al. Protein Sci, 2007 Sep. PMID 17660259, Free PMC Article

    See all (189) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synthesis of the NarP response regulator of nitrate respiration in Escherichia coli is regulated at multiple levels by Hfq and small RNAs.
      Title: Synthesis of the NarP response regulator of nitrate respiration in Escherichia coli is regulated at multiple levels by Hfq and small RNAs.
    2. Multiple in vivo roles for the C-terminal domain of the RNA chaperone Hfq.
      Title: Multiple in vivo roles for the C-terminal domain of the RNA chaperone Hfq.
    3. The association between Hfq and RNase E in long-term nitrogen-starved Escherichia coli.
      Title: The association between Hfq and RNase E in long-term nitrogen-starved Escherichia coli.
    4. Hfq and RNase R Mediate rRNA Processing and Degradation in a Novel RNA Quality Control Process.
      Title: Hfq and RNase R Mediate rRNA Processing and Degradation in a Novel RNA Quality Control Process.
    5. Translation inhibition from a distance: The small RNA SgrS silences a ribosomal protein S1-dependent enhancer.
      Title: Translation inhibition from a distance: The small RNA SgrS silences a ribosomal protein S1-dependent enhancer.
    6. RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment.
      Title: RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment.
    7. Optimization of a bacterial three-hybrid assay through in vivo titration of an RNA-DNA adapter protein.
      Title: Optimization of a bacterial three-hybrid assay through in vivo titration of an RNA-DNA adapter protein.
    8. Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation.
      Title: Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation.
    9. The RNA-binding protein Hfq assembles into foci-like structures in nitrogen starved Escherichia coli.
      Title: The RNA-binding protein Hfq assembles into foci-like structures in nitrogen starved Escherichia coli.
    10. Structure studies of an Escherichia coli Hfq Core and DNA complex reveals multifunctional binding sites.
      Title: Crystal structure of an Escherichia coli Hfq Core (residues 2-69)-DNA complex reveals multifunctional nucleic acid binding sites.
    Submit: New GeneRIF Correction See all GeneRIFs (78)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA folding chaperone EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables bent DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of translation, ncRNA-mediated IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation, ncRNA-mediated IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sRNA-mediated post-transcriptional gene silencing IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in tRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bacterial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding protein Hfq

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4400288..4400596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418593.1 RNA-binding protein Hfq [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418593.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376VR90
      Conserved Domains (1) summary
      PRK00395
      Location:1 → 76
      hfq; RNA-binding protein Hfq; Provisional
    Nucleotide Protein
    Heading Accession and Version

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