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    adiC arginine:agmatine antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948628, updated on 3-Dec-2024

    Summary

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    Official Symbol
    adiC
    Official Full Name
    arginine:agmatine antiporter
    Primary source
    ECOCYC:EG12462
    Locus tag
    b4115
    See related
    ASAP:ABE-0013473
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4108; yjdD; yjdE
    Summary
    EvgAS regulon. [More information is available at EcoGene: EG12462]. To survive in extremely acidic environments, Escherichia coli has evolved three acid resistance strategies. [More information is available at EcoCyc: EG12462].
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    Genomic context

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    Sequence:
    NC_000913.3 (4335694..4337031, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene small regulatory membrane protein PmrR Neighboring gene sensor histidine kinase BasS Neighboring gene DNA-binding transcriptional dual regulator BasR Neighboring gene phosphoethanolamine transferase EptA Neighboring gene DNA-binding transcriptional activator AdiY Neighboring gene arginine decarboxylase, degradative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unveiling the Mechanism of Arginine Transport through AdiC with Molecular Dynamics Simulations: The Guiding Role of Aromatic Residues. Krammer EM, et al. PLoS One, 2016. PMID 27482712, Free PMC Article
    2. Structure of a prokaryotic virtual proton pump at 3.2 A resolution. Fang Y, et al. Nature, 2009 Aug 20. PMID 19578361, Free PMC Article
    3. Structure and mechanism of an amino acid antiporter. Gao X, et al. Science, 2009 Jun 19. PMID 19478139
    4. Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC. Ilgü H, et al. Proc Natl Acad Sci U S A, 2016 Sep 13. PMID 27582465, Free PMC Article
    5. Projection structure of a member of the amino acid/polyamine/organocation transporter superfamily. Casagrande F, et al. J Biol Chem, 2008 Nov 28. PMID 18819925, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine:agmatine antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular stress response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arginine:agmatine antiporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4335694..4337031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418539.1 arginine:agmatine antiporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418539.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377CEC6
      Conserved Domains (1) summary
      PRK10644
      Location:1 → 445
      PRK10644; arginine/agmatine antiporter
    Nucleotide Protein
    Heading Accession and Version

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