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    ilvE branched-chain-amino-acid aminotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948278, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ilvE
    Official Full Name
    branched-chain-amino-acid aminotransferase
    Primary source
    ECOCYC:EG10497
    Locus tag
    b3770
    See related
    ASAP:ABE-0012316
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3762
    Summary
    Two independent determinations found N-terminal Gly where a Thr is encoded, indicating a modification of Thr to Gly may have occured post-translationally. [More information is available at EcoGene: EG10497]. Branched-chain amino acid transferase (IlvE) is a multifunctional enzyme that carries out the final step in valine, leucine and isoleucine biosyntheses. [More information is available at EcoCyc: EG10497].
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    Genomic context

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    Sequence:
    NC_000913.3 (3952484..3953413)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein IlvX Neighboring gene pseudo Neighboring gene acetolactate synthase II subunit IlvM Neighboring gene dihydroxy-acid dehydratase Neighboring gene threonine deaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemoenzymatic synthesis of glutamic acid analogues: substrate specificity and synthetic applications of branched chain aminotransferase from Escherichia coli. Xian M, et al. J Org Chem, 2007 Sep 28. PMID 17718503
    2. The ilvEDA operon of Escherichia coli K12 encodes only one valine-alpha-ketoglutarate transaminase activity. Adams CW, et al. Biochem Biophys Res Commun, 1979 Jul 27. PMID 385001
    3. Isoleucine and valine metabolism in Escherichia coli. V. alpha-Ketoisovaleric acid accumulation. ADELBERG EA, et al. J Biol Chem, 1953 Nov. PMID 13117924
    4. Crystal structures of branched-chain amino acid aminotransferase complexed with glutamate and glutarate: true reaction intermediate and double substrate recognition of the enzyme. Goto M, et al. Biochemistry, 2003 Apr 8. PMID 12667063
    5. Multivalent regulation of isoleucine-valine transaminase in an Escherichia coli K-12 ilvA deletion strain. Kline EL, et al. J Bacteriol, 1977 May. PMID 400801, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Branched-chain amino acid aminotransferase of Escherichia coli: overproduction and properties.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-isoleucine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-valine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables branched-chain-amino-acid transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-leucine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-leucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-valine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-valine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-valine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aspartate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within aspartate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branched-chain amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    branched-chain-amino-acid aminotransferase
    YP_026247.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3952484..3953413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026247.1 branched-chain-amino-acid aminotransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026247.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A828PFC7
      Conserved Domains (1) summary
      PRK06606
      Location:1 → 307
      PRK06606; branched-chain amino acid transaminase
    Nucleotide Protein
    Heading Accession and Version

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