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    yhaK bicupin-related protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947620, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yhaK
    Official Full Name
    bicupin-related protein
    Primary source
    ECOCYC:G7620
    Locus tag
    b3106
    See related
    ASAP:ABE-0010217
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3097
    Summary
    Yhak is a low abudance protein. yhhW and yhaK are paralogs, and homologs of human Pirin nuclear protein. [More information is available at EcoGene: EG12750]. YhaK belongs to a subclass of the bicupin family and may be involved in chloride binding or sensing of oxidative stress . [More information is available at EcoCyc: G7620].
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    Genomic context

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    Sequence:
    NC_000913.3 (3254319..3255020)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative inner membrane protein Neighboring gene DNA-binding transcriptional activator YhaJ Neighboring gene uncharacterized protein YhaL Neighboring gene putative L-cysteine desulfidase CyuA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide transposon mutagenesis identifies a role for host neuroendocrine stress hormones in regulating the expression of virulence genes in Salmonella. Spencer H, et al. J Bacteriol, 2010 Feb. PMID 19933366, Free PMC Article
    2. The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins. Gurmu D, et al. Proteins, 2009 Jan. PMID 18561187
    3. Prominent roles of the NorR and Fur regulators in the Escherichia coli transcriptional response to reactive nitrogen species. Mukhopadhyay P, et al. Proc Natl Acad Sci U S A, 2004 Jan 20. PMID 14718666, Free PMC Article
    4. Thermofluor-based high-throughput stability optimization of proteins for structural studies. Ericsson UB, et al. Anal Biochem, 2006 Oct 15. PMID 16962548
    5. Global gene expression profiling of asymptomatic bacteriuria Escherichia coli during biofilm growth in human urine. Hancock V, et al. Infect Immun, 2007 Feb. PMID 17145952, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bicupin-related protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3254319..3255020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417577.1 bicupin-related protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417577.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5D8MVT3
      Conserved Domains (1) summary
      COG1741
      Location:1 → 233
      YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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