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    infA translation initiation factor IF-1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945500, updated on 3-Dec-2024

    Summary

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    Official Symbol
    infA
    Official Full Name
    translation initiation factor IF-1
    Primary source
    ECOCYC:EG10504
    Locus tag
    b0884
    See related
    ASAP:ABE-0003005
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    bypA1; ECK0875
    Summary
    INfA acts as transcription antiterminator and has RNA chaperone activity in vivo and in vitro (Phadtare, 2007). [More information is available at EcoGene: EG10504]. IF-1 is one of three translation initiation factors in Escherichia coli and is essential for viability . [More information is available at EcoCyc: EG10504].
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    Genomic context

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    Sequence:
    NC_000913.3 (926225..926443, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-dependent Clp protease ATP-binding subunit ClpA Neighboring gene tRNA-Ser Neighboring gene leucyl/phenylalanyl-tRNA--protein transferase Neighboring gene glutathione/L-cysteine ABC exporter subunit CydC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function of initiation factor 1 in the binding and release of initiation factor 2 from ribosomal initiation complexes in Escherichia coli. Stringer EA, et al. J Biol Chem, 1977 Mar 10. PMID 320213
    2. Generation and characterization of functional mutants in the translation initiation factor IF1 of Escherichia coli. Croitoru V, et al. Eur J Biochem, 2004 Feb. PMID 14728680
    3. A host/plasmid system that is not dependent on antibiotics and antibiotic resistance genes for stable plasmid maintenance in Escherichia coli. Hägg P, et al. J Biotechnol, 2004 Jul 1. PMID 15196766
    4. In vivo involvement of mutated initiation factor IF1 in gene expression control at the translational level. Croitoru VV, et al. FEBS Lett, 2005 Feb 14. PMID 15710381
    5. Characterization of the domains of E. coli initiation factor IF2 responsible for recognition of the ribosome. Moreno JM, et al. FEBS Lett, 1999 Jul 16. PMID 10428486

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor IF-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      926225..926443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415404.1 translation initiation factor IF-1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415404.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P69222
      Conserved Domains (1) summary
      PRK00276
      Location:1 → 72
      infA; translation initiation factor IF-1; Validated
    Nucleotide Protein
    Heading Accession and Version

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