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    paoA aldehyde dehydrogenase, Fe-S subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945330, updated on 17-Dec-2024

    Summary

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    Official Symbol
    paoA
    Official Full Name
    aldehyde dehydrogenase, Fe-S subunit
    Primary source
    ECOCYC:G6157
    Locus tag
    b0286
    See related
    ASAP:ABE-0000992
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0285; yagT
    Summary
    Verified Tat substrate: [More information is available at EcoGene: EG13559]. YagR-YagS-YagT may be a heterotrimeric xanthine dehydrogenase . [More information is available at EcoCyc: G6157].
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    Genomic context

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    Sequence:
    NC_000913.3 (301884..302573, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative LysR family substrate binding domain-containing protein YagP Neighboring gene molybdenum cofactor insertion chaperone PaoD Neighboring gene aldehyde dehydrogenase: molybdenum cofactor-binding subunit Neighboring gene aldehyde dehydrogenase, FAD-binding subunit Neighboring gene DUF1440 domain-containing inner membrane protein YagU Neighboring gene putative metal-chelating domain-containing protein YkgJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a Rhodobacter capsulatus L-cysteine desulfurase that sulfurates the molybdenum cofactor when bound to XdhC and before its insertion into xanthine dehydrogenase. Neumann M, et al. Biochemistry, 2007 Aug 21. PMID 17649978
    2. A periplasmic aldehyde oxidoreductase represents the first molybdopterin cytosine dinucleotide cofactor containing molybdo-flavoenzyme from Escherichia coli. Neumann M, et al. FEBS J, 2009 May. PMID 19368556
    3. Pathfinders and trailblazers: a prokaryotic targeting system for transport of folded proteins. Sargent F, et al. FEMS Microbiol Lett, 2006 Jan. PMID 16445746
    4. Protein targeting by the bacterial twin-arginine translocation (Tat) pathway. Berks BC, et al. Curr Opin Microbiol, 2005 Apr. PMID 15802249
    5. The Tat protein translocation pathway and its role in microbial physiology. Berks BC, et al. Adv Microb Physiol, 2003. PMID 14560665

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular detoxification of aldehyde IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oxidoreductase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic space NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldehyde dehydrogenase, Fe-S subunit
    NP_414820.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      301884..302573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414820.1 aldehyde dehydrogenase, Fe-S subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414820.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAV3IB17
      Conserved Domains (1) summary
      PRK11433
      Location:12 → 228
      PRK11433; aldehyde oxidoreductase 2Fe-2S subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version

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