U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nudG 5-hydroxy-CTP diphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946277, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nudG
    Official Full Name
    5-hydroxy-CTP diphosphatase
    Primary source
    ECOCYC:G6954
    Locus tag
    b1759
    See related
    ASAP:ABE-0005855
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1757; orf135; ynjG
    Summary
    Nudix hydrolase. [More information is available at EcoGene: EG14009]. NudG is a member of the Nudix hydrolase family and shows high specificity for hydrolysis of pyrimidine (deoxy)nucleoside triphosphates . [More information is available at EcoCyc: G6954].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1841490..1841897)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene molybdopterin synthase sulfurtransferase Neighboring gene CDP-alcohol phosphatidyltransferase domain-containing protein YnjF Neighboring gene DUF1496 domain-containing protein YnjH Neighboring gene glutamate dehydrogenase Neighboring gene DUF1266 domain-containing protein YnjI

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Suppression of spontaneous and hydrogen peroxide-induced mutations by a MutT-type nucleotide pool sanitization enzyme, the Escherichia coli Orf135 protein. Kamiya H, et al. Genes Cells, 2003 Dec. PMID 14750949
    2. Hydrolysis of oxidized nucleotides by the Escherichia coli Orf135 protein. Kamiya H, et al. Biochem Biophys Res Commun, 2001 Nov 2. PMID 11676470
    3. Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP. O'Handley SF, et al. J Biol Chem, 2001 Feb 23. PMID 11053429
    4. Mutagenesis by damaged deoxyribonucleotides and its prevention by MutT-type hydrolyzing enzymes. Kamiya H, et al. Nucleic Acids Symp Ser (Oxf), 2004. PMID 17150583
    5. Insights into substrate recognition by the Escherichia coli Orf135 protein through its solution structure. Kawasaki K, et al. Biochem Biophys Res Commun, 2012 Apr 6. PMID 22414689

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 8-oxo-GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 8-oxo-dGDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dCTP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    5-hydroxy-CTP diphosphatase
    NP_416273.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1841490..1841897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416273.1 5-hydroxy-CTP diphosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416273.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAE9PYC1
      Conserved Domains (1) summary
      PRK10546
      Location:1 → 135
      PRK10546; pyrimidine (deoxy)nucleoside triphosphate diphosphatase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.