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    MRX15 Mrx15p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855776, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MRX15
    Official Full Name
    Mrx15p
    Primary source
    SGD:S000005323
    Locus tag
    YNR040W
    See related
    AllianceGenome:SGD:S000005323; FungiDB:YNR040W; VEuPathDB:YNR040W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DPI29
    Summary
    Enables mitochondrial ribosome binding activity. Involved in protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MRX15 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (699690..700460)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative ATP-dependent RNA helicase DBP6 Neighboring gene Zn(2+) transporter ZRG17 Neighboring gene 4-hydroxybenzoate octaprenyltransferase Neighboring gene diphosphomevalonate decarboxylase MVD1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insertion Defects of Mitochondrially Encoded Proteins Burden the Mitochondrial Quality Control System. Vargas Möller-Hergt B, et al. Cells, 2018 Oct 17. PMID 30336542, Free PMC Article
    2. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Morgenstern M, et al. Cell Rep, 2017 Jun 27. PMID 28658629, Free PMC Article
    3. A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation. De Muyt A, et al. Genes Dev, 2018 Feb 1. PMID 29440262, Free PMC Article
    4. Synchronized assembly of the oxidative phosphorylation system controls mitochondrial respiration in yeast. Moretti-Horten DN, et al. Dev Cell, 2024 Apr 22. PMID 38508182
    5. Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation. Sanchez A, et al. Proc Natl Acad Sci U S A, 2020 Dec 1. PMID 33199619, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mitochondrial ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mitochondrial ribosome binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane from matrix IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Mrx15p
    NP_014438.3
    • Membrane-associated mitoribosome receptor; involved along with Mba1p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with the mitochondrial large ribosomal subunit and nascent polypeptide chains; null mutant displays increased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      699690..700460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183217.3 → NP_014438.3  TPA: Mrx15p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014438.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1L6, P53736
      UniProtKB/TrEMBL
      B3LPK2, B5VR67, C7GLL6, N1NXT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53736.1

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