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    acrD multidrug efflux pump RND permease AcrD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945464, updated on 3-Dec-2024

    Summary

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    Official Symbol
    acrD
    Official Full Name
    multidrug efflux pump RND permease AcrD
    Primary source
    ECOCYC:EG10014
    Locus tag
    b2470
    See related
    ASAP:ABE-0008136
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2465; yffA
    Summary
    acrD mutation confers increased sensitivity to aminoglycosides. acrD is paralogous to acrB. [More information is available at EcoGene: EG10014]. [More information is available at EcoCyc: EG10014].
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    Genomic context

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    Sequence:
    NC_000913.3 (2587595..2590708)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase AegA Neighboring gene sensor histidine kinase NarQ Neighboring gene uncharacterized protein YpfM Neighboring gene putative reductase YffB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efflux-mediated multiresistance in Gram-negative bacteria. Poole K. Clin Microbiol Infect, 2004 Jan. PMID 14706082
    2. Substrate-dependent dynamics of the multidrug efflux transporter AcrB of Escherichia coli. Yamamoto K, et al. Sci Rep, 2016 Feb 26. PMID 26916090, Free PMC Article
    3. Resistance against antimicrobial peptides is independent of Escherichia coli AcrAB, Pseudomonas aeruginosa MexAB and Staphylococcus aureus NorA efflux pumps. Rieg S, et al. Int J Antimicrob Agents, 2009 Feb. PMID 18945595
    4. Characterisation of cisplatin coordination sites in cellular Escherichia coli DNA-binding proteins by combined biphasic liquid chromatography and ESI tandem mass spectrometry. Will J, et al. J Biol Inorg Chem, 2008 Mar. PMID 18157731
    5. Novel acriflavin resistance genes, acrC and acrD, in Escherichia coli K-12. Nakamura H. J Bacteriol, 1979 Jul. PMID 378962, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AcrBA-TolC complex becomes unstable upon the induction of AcrD, which presumably replaces AcrB in the ternary complex. Such instability is suppressed upon the addition of AcrB-specific substrates. The assembly of resistance-nodulation-cell division-type efflux system is a regulated dynamic process that provides bacteria with a highly flexible repertoire of survival strategies to cope with a wide spectrum of antibiotics.
      Title: Substrate-dependent dynamics of the multidrug efflux transporter AcrB of Escherichia coli.
    2. multiple deletion of acrB, acrD, and mdtABC resulted in a significant decrease in enterobactin export and that plasmids carrying the acrAB, acrD, or mdtABC genes restored the decrease in enterobactin export exhibited by the DeltaacrB acrD mdtABC mutant.
      Title: AcrB, AcrD, and MdtABC multidrug efflux systems are involved in enterobactin export in Escherichia coli.
    3. AcrD can also capture aminoglycosides from the periplasm to extrude them into the medium in intact cells, acting as a "periplasmic vacuum cleaner."
      Title: Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables efflux transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in xenobiotic transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of efflux pump complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of efflux pump complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multidrug efflux pump RND permease AcrD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2587595..2590708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416965.1 multidrug efflux pump RND permease AcrD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416965.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9X022, A0A8S7R0G6
      Conserved Domains (1) summary
      PRK10555
      Location:1 → 1037
      PRK10555; multidrug efflux RND transporter permease AcrD
    Nucleotide Protein
    Heading Accession and Version

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