U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cobS cobalamin 5'-phosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946520, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cobS
    Official Full Name
    cobalamin 5'-phosphate synthase
    Primary source
    ECOCYC:EG12150
    Locus tag
    b1992
    See related
    ASAP:ABE-0006613
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1987
    Summary
    Escherichia coli K-12, as well as natural isolates, can synthesize cobalamin only when supplied with the intermediate cobinamide . cobS encodes a predicted cobalamin synthase . [More information is available at EcoCyc: EG12150].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2064479..2065222, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L,D-transpeptidase LdtA Neighboring gene nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Neighboring gene cobinamide-P guanylyltransferase/cobinamide kinase Neighboring gene pseudo Neighboring gene IS5 family transposase and trans-activator

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex. Lawrence JG, et al. Genetics, 1996 Jan. PMID 8770581, Free PMC Article
    2. The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli. Lawrence JG, et al. J Bacteriol, 1995 Nov. PMID 7592411, Free PMC Article
    3. A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. Itoh T, et al. DNA Res, 1996 Dec 31. PMID 9097040
    4. Global topology analysis of the Escherichia coli inner membrane proteome. Daley DO, et al. Science, 2005 May 27. PMID 15919996
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables adenosylcobinamide-GDP ribazoletransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables adenosylcobinamide-GDP ribazoletransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cobalamin 5'-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cobalamin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cobalamin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cobalamin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cobalamin 5'-phosphate synthase
    NP_416496.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2064479..2065222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416496.1 cobalamin 5'-phosphate synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416496.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376WWL8, A0A7A7AY87, A0A8T6PUF3
      Conserved Domains (1) summary
      TIGR00317
      Location:1 → 246
      cobS; cobalamin 5'-phosphate synthase/cobalamin synthase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.