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    arnD putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945334, updated on 17-Dec-2024

    Summary

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    Official Symbol
    arnD
    Official Full Name
    putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
    Primary source
    ECOCYC:G7169
    Locus tag
    b2256
    See related
    ASAP:ABE-0007462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2249; pmrJ; yfbH
    Summary
    An arnD mutant strain accumulates formylated C55-P-LAra4N and blocks C55-P-LAra4N production, supporting the deformaylase functional assignment (S.D. [More information is available at EcoGene: EG14092]. ArnD is predicted to act as a deformylase that removes the formyl group from undecaprenyl phosphate-L-Ara4FN . [More information is available at EcoCyc: G7169].
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    Genomic context

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    Sequence:
    NC_000913.3 (2370018..2370908)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-4-amino-4-deoxy-L-arabinose aminotransferase Neighboring gene undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Neighboring gene fused UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronate dehydrogenase Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit Neighboring gene signal transduction protein PmrD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The pleiotropic two-component regulatory system PhoP-PhoQ. Groisman EA. J Bacteriol, 2001 Mar. PMID 11222580, Free PMC Article
    2. Fe(III)-mediated cellular toxicity. Chamnongpol S, et al. Mol Microbiol, 2002 Aug. PMID 12139617
    3. Role of Mg2+ and pH in the modification of Salmonella lipid A after endocytosis by macrophage tumour cells. Gibbons HS, et al. Mol Microbiol, 2005 Jan. PMID 15659161
    4. An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. Yan A, et al. J Biol Chem, 2007 Dec 7. PMID 17928292, Free PMC Article
    5. Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm. Trent MS, et al. J Biol Chem, 2001 Nov 16. PMID 11535605

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to iron(III) ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to iron(III) ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2370018..2370908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416759.1 putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416759.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FPX7
      Conserved Domains (1) summary
      PRK15394
      Location:1 → 291
      PRK15394; 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional
    Nucleotide Protein
    Heading Accession and Version

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