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    hflK regulator of FtsH protease [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948698, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hflK
    Official Full Name
    regulator of FtsH protease
    Primary source
    ECOCYC:EG10436
    Locus tag
    b4174
    See related
    ASAP:ABE-0013663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4170; hflA; hslY
    Summary
    Gain-of-function alleles in hflC and hflK inhibit FtsH-mediated degradation of uncomplexed SecY protein and other membrane protein substrates. [More information is available at EcoGene: EG10436]. The HflK-HflC (HflKC) complex interacts with FtsH and regulates (inhibits) proteolysis by FtsH of SecY and lambda cII protein . [More information is available at EcoCyc: EG10436].
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    Genomic context

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    Sequence:
    NC_000913.3 (4402038..4403297)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA-binding protein Hfq Neighboring gene ribosome rescue factor HflX Neighboring gene regulator of FtsH protease Neighboring gene DUF2065 domain-containing protein YjeT

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane localization of the HflA regulatory protease of Escherichia coli by immunoelectron microscopy. Zorick TS, et al. J Bacteriol, 1991 Oct. PMID 1833381, Free PMC Article
    2. A class of Escherichia coli proteins controlled by the hflA locus. Cheng HH, et al. J Mol Biol, 1987 Aug 5. PMID 2824788
    3. Cleavage of the cII protein of phage lambda by purified HflA protease: control of the switch between lysis and lysogeny. Cheng HH, et al. Proc Natl Acad Sci U S A, 1988 Nov. PMID 2973057, Free PMC Article
    4. Genetic and biochemical investigation of the Escherichia coli mutant hfl-1 which is lysogenized at high frequency by bacteriophage lambda. Belfort M, et al. J Bacteriol, 1973 Jul. PMID 4352176, Free PMC Article
    5. An analysis of the processes of infection and induction of E. coli mutant hfl-1 by bacteriophage lambda. Belfort M, et al. Virology, 1973 Sep. PMID 4580731

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HflKC inhibits the proteolysis of lambdaCII by HflB and hence the overexpression of the former results in an increase in the lysogenic frequency.
      Title: Studies on Escherichia coli HflKC suggest the presence of an unidentified λ factor that influences the lysis-lysogeny switch.
    2. report the first purification of HflK and HflC separately as active and functional proteins and show that each can interact with HflB on its own and each inhibits the proteolysis of lambdaCII
      Title: Escherichia coli HflK and HflC can individually inhibit the HflB (FtsH)-mediated proteolysis of lambdaCII in vitro.
    3. These results demonstrate the importance of right-handed coiled-coil interactions in the oligomerization of HflKC, and a model entailing the formation of a right-handed helical barrel is proposed.
      Title: The periplasmic domains of Escherichia coli HflKC oligomerize through right-handed coiled-coil interactions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of plasma membrane protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of FtsH protease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4402038..4403297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418595.1 regulator of FtsH protease [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418595.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AME3
      Conserved Domains (1) summary
      PRK10930
      Location:1 → 419
      PRK10930; FtsH protease activity modulator HflK
    Nucleotide Protein
    Heading Accession and Version

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