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    cof HMP-PP phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945089, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cof
    Official Full Name
    HMP-PP phosphatase
    Primary source
    ECOCYC:G6246
    Locus tag
    b0446
    See related
    ASAP:ABE-0001548
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0440
    Summary
    Cloned cof complements fur deletion mutant for growth on succinate: this gene name and function have only been reported as an annotation in EMBL entry Z54355, Patzer, S.I. and Hantke, K., 1995. [More information is available at EcoGene: EG13216]. Cof is a phosphatase belonging to the superfamily of haloacid dehalogenase (HAD)-like hydrolases. [More information is available at EcoCyc: G6246].
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    Genomic context

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    Sequence:
    NC_000913.3 (467412..468230)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 7-cyano-7-deazaguanine synthase Neighboring gene uncharacterized protein YbaE Neighboring gene DNA-binding transcriptional activator DecR Neighboring gene ABC transporter family protein MdlA Neighboring gene ABC transporter family protein MdlB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screen for the identification of thiamin metabolic genes. Lawhorn BG, et al. J Biol Chem, 2004 Oct 15. PMID 15292217
    2. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Arifuzzaman M, et al. Genome Res, 2006 May. PMID 16606699, Free PMC Article
    3. Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. Kuznetsova E, et al. J Biol Chem, 2006 Nov 24. PMID 16990279
    4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
    5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibiotic catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within thiamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HMP-PP phosphatase
    NP_414980.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      467412..468230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414980.2 HMP-PP phosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414980.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WVG4, A0A6N8R372
      Conserved Domains (1) summary
      PRK15126
      Location:1 → 272
      PRK15126; HMP-PP phosphatase
    Nucleotide Protein
    Heading Accession and Version

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