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    dapE succinyl-diaminopimelate desuccinylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948313, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dapE
    Official Full Name
    succinyl-diaminopimelate desuccinylase
    Primary source
    ECOCYC:EG10208
    Locus tag
    b2472
    See related
    ASAP:ABE-0008142
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2467; msgB
    Summary
    A dapE mutant is not in the Keio collection; DAP auxotrophs require added DAP to grow and since no DAP was added during mutant construction, no auxotrophic mutants were recovered; dapE is not an essential gene (Baba, 2006). dapE(msgB) is a multicopy suppressor of grpE(Ts). [More information is available at EcoGene: EG10208]. The Escherichia coli N-succinyl-L-diaminopimelate desuccinylase exists as a mixture of homodimers and homotetramers. [More information is available at EcoCyc: EG10208].
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    Genomic context

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    Sequence:
    NC_000913.3 (2591607..2592734)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YpfM Neighboring gene putative reductase YffB Neighboring gene PF13980 family protein YpfN Neighboring gene esterase YpfH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The essential Escherichia coli msgB gene, a multicopy suppressor of a temperature-sensitive allele of the heat shock gene grpE, is identical to dapE. Wu B, et al. J Bacteriol, 1992 Aug. PMID 1644751, Free PMC Article
    2. Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity. Gillner D, et al. Bioorg Med Chem Lett, 2009 Nov 15. PMID 19822427
    3. Bacterial N-succinyl-L-diaminopimelic acid desuccinylase. Purification, partial characterization, and substrate specificity. Lin YK, et al. J Biol Chem, 1988 Feb 5. PMID 3276674
    4. Chromosomal location and nucleotide sequence of the Escherichia coli dapA gene. Richaud F, et al. J Bacteriol, 1986 Apr. PMID 3514578, Free PMC Article
    5. Identification of the purC gene product of Escherichia coli. Parker J. J Bacteriol, 1984 Mar. PMID 6365889, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cobalt ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables succinyl-diaminopimelate desuccinylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinyl-diaminopimelate desuccinylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinyl-diaminopimelate desuccinylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinyl-diaminopimelate desuccinylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within FtsZ-dependent cytokinesis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in diaminopimelate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via diaminopimelate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysine biosynthetic process via diaminopimelate IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinyl-diaminopimelate desuccinylase
    NP_416967.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2591607..2592734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416967.1 succinyl-diaminopimelate desuccinylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416967.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C9ABL5, A0A8T5Y6Y3
      Conserved Domains (1) summary
      PRK13009
      Location:2 → 375
      PRK13009; succinyl-diaminopimelate desuccinylase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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