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    mdtG efflux pump MdtG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945627, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mdtG
    Official Full Name
    efflux pump MdtG
    Primary source
    ECOCYC:EG11343
    Locus tag
    b1053
    See related
    ASAP:ABE-0003572
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1038; yceE
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG11343]. The YceE protein is, based on sequence similarity and hydropathy, a member of the major facilitator superfamily (MFS) . [More information is available at EcoCyc: EG11343].
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    Genomic context

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    Sequence:
    NC_000913.3 (1114264..1115490, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1375 domain-containing lipoprotein YceK Neighboring gene acidic protein MsyB Neighboring gene lauroyl acyltransferase Neighboring gene tRNA U34 hydroxylase TrhO

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. Fàbrega A, et al. Antimicrob Agents Chemother, 2010 Mar. PMID 20008776, Free PMC Article
    2. Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes. Paulsen IT, et al. J Mol Biol, 2000 Aug 4. PMID 10926494
    3. Proton-dependent multidrug efflux systems. Paulsen IT, et al. Microbiol Rev, 1996 Dec. PMID 8987357, Free PMC Article
    4. Multicopy suppression: an approach to understanding intracellular functioning of the protein export system. Ueguchi C, et al. J Bacteriol, 1992 Mar. PMID 1537791, Free PMC Article
    5. Analysis of a complete library of putative drug transporter genes in Escherichia coli. Nishino K, et al. J Bacteriol, 2001 Oct. PMID 11566977, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings showed that mdtG, encoding a putative efflux pump, is overexpressed in the fluoroquinolone resistant strain.
      Title: Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to paraquat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    efflux pump MdtG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1114264..1115490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415571.1 efflux pump MdtG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415571.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A403CZ15
      Conserved Domains (1) summary
      PRK09874
      Location:1 → 408
      PRK09874; multidrug efflux MFS transporter MdtG
    Nucleotide Protein
    Heading Accession and Version

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