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    Csrp3 cysteine and glycine-rich protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 13009, updated on 9-Dec-2024

    Summary

    Official Symbol
    Csrp3provided by MGI
    Official Full Name
    cysteine and glycine-rich protein 3provided by MGI
    Primary source
    MGI:MGI:1330824
    See related
    Ensembl:ENSMUSG00000030470 AllianceGenome:MGI:1330824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MLP; CRP3; MMLP
    Summary
    Enables actinin binding activity and telethonin binding activity. A structural constituent of muscle. Involved in several processes, including cardiac muscle contraction; cardiac myofibril assembly; and detection of muscle stretch. Acts upstream of or within several processes, including T-tubule organization; insulin receptor signaling pathway; and muscle cell cellular homeostasis. Located in Z disc. Is expressed in several structures, including genitourinary system; great vessel of heart; heart; limb segment; and skeletal musculature. Used to study congestive heart failure; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward heart adult (RPKM 191.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Csrp3 in Genome Data Viewer
    Location:
    7 B4; 7 31.11 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (48480146..48497799, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (48830398..48848051, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32263 Neighboring gene STARR-positive B cell enhancer ABC_E1734 Neighboring gene zinc finger, DHHC domain containing 13 Neighboring gene STARR-seq mESC enhancer starr_18887 Neighboring gene STARR-positive B cell enhancer ABC_E3719 Neighboring gene STARR-positive B cell enhancer ABC_E8174 Neighboring gene E2F transcription factor 8 Neighboring gene predicted gene 2788 Neighboring gene STARR-seq mESC enhancer starr_18888 Neighboring gene STARR-seq mESC enhancer starr_18889 Neighboring gene RAN, member RAS oncogene family pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MRF binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actinin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of muscle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
     
    enables telethonin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables telethonin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T-tubule organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cardiac myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of muscle stretch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of muscle stretch ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of actin filament severing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phospholipase C/protein kinase C signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of actin filament severing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of the force of heart contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cysteine and glycine-rich protein 3
    Names
    LIM domain protein, cardiac
    cardiac LIM protein
    cysteine-rich protein 3
    muscle LIM protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198841.1NP_001185770.1  cysteine and glycine-rich protein 3

      See identical proteins and their annotated locations for NP_001185770.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC061131, BG793105, BY067937
      Consensus CDS
      CCDS21305.1
      UniProtKB/Swiss-Prot
      P50462
      UniProtKB/TrEMBL
      Q545C7
      Related
      ENSMUSP00000032658.7, ENSMUST00000032658.14
      Conserved Domains (2) summary
      cd09481
      Location:962
      LIM1_CRP3; The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
      cd09482
      Location:120173
      LIM2_CRP3; The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
    2. NM_013808.4NP_038836.1  cysteine and glycine-rich protein 3

      See identical proteins and their annotated locations for NP_038836.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI314553, BC061131
      Consensus CDS
      CCDS21305.1
      UniProtKB/Swiss-Prot
      P50462
      UniProtKB/TrEMBL
      Q545C7
      Related
      ENSMUSP00000129378.3, ENSMUST00000167786.4
      Conserved Domains (2) summary
      cd09481
      Location:962
      LIM1_CRP3; The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
      cd09482
      Location:120173
      LIM2_CRP3; The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      48480146..48497799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)