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    Ninj1 ninjurin 1 [ Mus musculus (house mouse) ]

    Gene ID: 18081, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ninj1provided by MGI
    Official Full Name
    ninjurin 1provided by MGI
    Primary source
    MGI:MGI:1196617
    See related
    Ensembl:ENSMUSG00000037966 AllianceGenome:MGI:1196617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables cell-cell adhesion mediator activity; lipopolysaccharide binding activity; and membrane destabilizing activity. Involved in several processes, including ferroptosis; leukocyte chemotaxis; and positive regulation of defense response. Acts upstream of or within hyaloid vascular plexus regression and positive regulation of cell-matrix adhesion. Located in extracellular region; filopodium membrane; and synaptic membrane. Is active in plasma membrane. Is expressed in several structures, including body cavity or lining; central nervous system; eye; genitourinary system; and vertebral axis musculature. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 287.9), kidney adult (RPKM 192.9) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Ninj1 in Genome Data Viewer
    Location:
    13 A5; 13 25.14 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49341005..49349727)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49187529..49196251)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40942 Neighboring gene predicted gene, 40943 Neighboring gene caspase recruitment domain family, member 19 Neighboring gene STARR-positive B cell enhancer ABC_E7237 Neighboring gene STARR-positive B cell enhancer ABC_E5396 Neighboring gene predicted gene, 52024 Neighboring gene sushi domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in cell adhesion  
    involved_in cell adhesion PubMed 
    involved_in cell adhesion PubMed 
    involved_in cell adhesion  
    involved_in cellular hyperosmotic response PubMed 
    involved_in chemotaxis PubMed 
    involved_in cytolysis PubMed 
    involved_in ferroptosis PubMed 
    involved_in heterotypic cell-cell adhesion PubMed 
    acts_upstream_of_or_within hyaloid vascular plexus regression PubMed 
    involved_in inflammatory response PubMed 
    involved_in inflammatory response  
    involved_in inflammatory response  
    involved_in killing of cells of another organism  
    involved_in leukocyte chemotaxis involved in inflammatory response PubMed 
    involved_in leukocyte chemotaxis involved in inflammatory response PubMed 
    involved_in leukocyte chemotaxis involved in inflammatory response  
    involved_in macrophage chemotaxis PubMed 
    involved_in muscle cell differentiation PubMed 
    involved_in pericyte cell migration PubMed 
    involved_in positive regulation of angiogenesis  
    acts_upstream_of_or_within positive regulation of cell-matrix adhesion PubMed 
    involved_in positive regulation of inflammatory response PubMed 
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of osteoclast development PubMed 
    involved_in positive regulation of toll-like receptor 4 signaling pathway PubMed 
    involved_in programmed cell death  
    involved_in programmed necrotic cell death PubMed 
    involved_in protein homooligomerization PubMed 
    involved_in protein homooligomerization  
    involved_in pyroptotic cell death PubMed 
    involved_in pyroptotic inflammatory response  
    involved_in regulation of angiogenesis PubMed 
    involved_in regulation of monocyte chemotaxis PubMed 
    involved_in regulation of monocyte chemotaxis  
    involved_in tissue regeneration  
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    located_in extracellular region PubMed 
    located_in extracellular region  
    is_active_in extracellular region  
    located_in filopodium membrane PubMed 
    is_active_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    is_active_in plasma membrane  
    located_in synaptic membrane PubMed 

    General protein information

    Preferred Names
    ninjurin-1
    Names
    nerve injury-induced protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013610.3NP_038638.1  ninjurin-1

      See identical proteins and their annotated locations for NP_038638.1

      Status: VALIDATED

      Source sequence(s)
      AK159111, BB756836
      Consensus CDS
      CCDS26497.1
      UniProtKB/Swiss-Prot
      O70131
      UniProtKB/TrEMBL
      Q3TXT8, Q8BP68
      Related
      ENSMUSP00000036740.9, ENSMUST00000049022.15
      Conserved Domains (1) summary
      pfam04923
      Location:39139
      Ninjurin; Ninjurin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      49341005..49349727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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