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    Nfat5 nuclear factor of activated T cells 5 [ Mus musculus (house mouse) ]

    Gene ID: 54446, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nfat5provided by MGI
    Official Full Name
    nuclear factor of activated T cells 5provided by MGI
    Primary source
    MGI:MGI:1859333
    See related
    Ensembl:ENSMUSG00000003847 AllianceGenome:MGI:1859333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAG-8; CAG80; OREBP; nfatz; NFATL1; TonEBP; mKIAA0827; B130038B15Rik
    Summary
    Enables DNA binding activity. Acts upstream of or within positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; and regulation of calcineurin-NFAT signaling cascade. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human NFAT5 (nuclear factor of activated T cells 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 18.9), bladder adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nfat5 in Genome Data Viewer
    Location:
    8 D3; 8 53.93 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (108020072..108106149)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107293435..107379517)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930517G24 gene Neighboring gene STARR-seq mESC enhancer starr_22599 Neighboring gene ribosomal protein S18, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_22600 Neighboring gene STARR-positive B cell enhancer ABC_E9742 Neighboring gene predicted gene, 51546 Neighboring gene STARR-seq mESC enhancer starr_22601 Neighboring gene NAD(P)H dehydrogenase, quinone 1 Neighboring gene STARR-positive B cell enhancer ABC_E8262 Neighboring gene NIN1/RPN12 binding protein 1 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in R-loop processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in R-loop processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to cytokine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of urine volume TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of calcineurin-NFAT signaling cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of renal water homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to water deprivation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    nuclear factor of activated T-cells 5
    Names
    T-cell transcription factor NFAT5
    rel domain-containing transcription factor NFAT5
    tonicity-responsive enhancer binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286260.1NP_001273189.1  nuclear factor of activated T-cells 5 isoform c

      See identical proteins and their annotated locations for NP_001273189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) uses an alternate splice site and lacks a portion of the 3' coding region, compared to variant b. This results in a shorter protein (isoform c) with a distinct C-terminus, compared to variant b.
      Source sequence(s)
      AC158364, AK052632, AK134022, BE633760
      Consensus CDS
      CCDS72168.1
      UniProtKB/Swiss-Prot
      Q9WV30
      UniProtKB/TrEMBL
      Q3UZ77
      Related
      ENSMUSP00000075311.5, ENSMUST00000075922.11
      Conserved Domains (2) summary
      cd07882
      Location:280440
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:444543
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    2. NM_018823.2NP_061293.2  nuclear factor of activated T-cells 5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) encodes the longest isoform (b).
      Source sequence(s)
      AC158364, AF200687, AF369980, AK045123, BE633760
      Consensus CDS
      CCDS22648.2
      UniProtKB/TrEMBL
      Q8VHJ6
      Related
      ENSMUSP00000127784.2, ENSMUST00000169453.8
      Conserved Domains (2) summary
      cd07882
      Location:298458
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:462561
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    3. NM_133957.3NP_598718.2  nuclear factor of activated T-cells 5 isoform a

      See identical proteins and their annotated locations for NP_598718.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon. This results in a protein (isoform a) with a shorter N-terminus, compared to isoform b.
      Source sequence(s)
      AC158364, AF200687, AF369980, AK045123, BE633760
      Consensus CDS
      CCDS40464.1
      UniProtKB/TrEMBL
      A0A1U6URG8, Q8VHJ6
      Conserved Domains (3) summary
      cd07882
      Location:204364
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:368467
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      pfam09606
      Location:11241365
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      108020072..108106149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531192.4XP_006531255.1  nuclear factor of activated T-cells 5 isoform X2

      See identical proteins and their annotated locations for XP_006531255.1

      UniProtKB/Swiss-Prot
      E9Q0P3, E9Q6U2, G5E8N9, Q91WY0, Q9JLA1, Q9WV30
      UniProtKB/TrEMBL
      Q8VHJ6
      Related
      ENSMUSP00000116094.2, ENSMUST00000125721.8
      Conserved Domains (3) summary
      cd07882
      Location:280440
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:444543
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      pfam09606
      Location:12001441
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    2. XM_030243679.1XP_030099539.1  nuclear factor of activated T-cells 5 isoform X3

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (3) summary
      cd07882
      Location:280440
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:444543
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      pfam09606
      Location:11991440
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    3. XM_030243680.1XP_030099540.1  nuclear factor of activated T-cells 5 isoform X5

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (3) summary
      cd07882
      Location:233393
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:397496
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      pfam09606
      Location:11531394
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    4. XM_030243681.2XP_030099541.1  nuclear factor of activated T-cells 5 isoform X6

      UniProtKB/TrEMBL
      A0A1U6URG8, Q8VHJ6
      Related
      ENSMUSP00000076653.7, ENSMUST00000077440.13
      Conserved Domains (3) summary
      cd07882
      Location:204364
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:368467
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      pfam09606
      Location:11241365
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    5. XM_006531191.4XP_006531254.1  nuclear factor of activated T-cells 5 isoform X1

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (3) summary
      cd07882
      Location:298458
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:462561
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      pfam09606
      Location:12171458
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    6. XM_006531193.4XP_006531256.1  nuclear factor of activated T-cells 5 isoform X4

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (3) summary
      cd07882
      Location:251411
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:415514
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      pfam09606
      Location:11711412
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    7. XM_036154180.1XP_036010073.1  nuclear factor of activated T-cells 5 isoform X7

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (2) summary
      cd07882
      Location:204364
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:368467
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    8. XM_036154184.1XP_036010077.1  nuclear factor of activated T-cells 5 isoform X11

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (2) summary
      cd07882
      Location:56216
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:220319
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    9. XM_006531194.3XP_006531257.1  nuclear factor of activated T-cells 5 isoform X8

      See identical proteins and their annotated locations for XP_006531257.1

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (2) summary
      cd07882
      Location:98258
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:262361
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    10. XM_006531196.3XP_006531259.1  nuclear factor of activated T-cells 5 isoform X9

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (2) summary
      cd07882
      Location:74234
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:238337
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    11. XM_030243682.2XP_030099542.1  nuclear factor of activated T-cells 5 isoform X8

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (2) summary
      cd07882
      Location:98258
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:262361
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    12. XM_036154182.1XP_036010075.1  nuclear factor of activated T-cells 5 isoform X9

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (2) summary
      cd07882
      Location:74234
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:238337
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    13. XM_036154181.1XP_036010074.1  nuclear factor of activated T-cells 5 isoform X8

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (2) summary
      cd07882
      Location:98258
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:262361
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    14. XM_036154183.1XP_036010076.1  nuclear factor of activated T-cells 5 isoform X10

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (2) summary
      cd07882
      Location:74234
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:238337
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    15. XM_017312904.3XP_017168393.1  nuclear factor of activated T-cells 5 isoform X6

      UniProtKB/TrEMBL
      A0A1U6URG8, Q8VHJ6
      Conserved Domains (3) summary
      cd07882
      Location:204364
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:368467
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      pfam09606
      Location:11241365
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    16. XM_017312905.3XP_017168394.1  nuclear factor of activated T-cells 5 isoform X8

      UniProtKB/TrEMBL
      Q8VHJ6
      Conserved Domains (2) summary
      cd07882
      Location:98258
      RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
      cd01178
      Location:262361
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.