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    Fam50a family with sequence similarity 50, member A [ Mus musculus (house mouse) ]

    Gene ID: 108160, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fam50aprovided by MGI
    Official Full Name
    family with sequence similarity 50, member Aprovided by MGI
    Primary source
    MGI:MGI:1351626
    See related
    Ensembl:ENSMUSG00000001962 AllianceGenome:MGI:1351626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XAP-5; D0HXS9928E
    Summary
    Predicted to be involved in chromatin organization and regulation of RNA splicing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Armfield syndrome. Orthologous to human FAM50A (family with sequence similarity 50 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 17.7), CNS E11.5 (RPKM 17.2) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fam50a in Genome Data Viewer
    Location:
    X A7.3; X 37.98 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73356589..73363761)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74313033..74320149)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7694 Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 1 Neighboring gene GDP dissociation inhibitor 1 Neighboring gene microRNA 7092 Neighboring gene predicted gene, 39520 Neighboring gene plexin A3 Neighboring gene L antigen family, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein FAM50A
    Names
    protein XAP-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138607.3NP_613073.2  protein FAM50A

      See identical proteins and their annotated locations for NP_613073.2

      Status: VALIDATED

      Source sequence(s)
      AK008402, Y18505
      Consensus CDS
      CCDS41021.1
      UniProtKB/Swiss-Prot
      Q9D866, Q9WV03
      UniProtKB/TrEMBL
      A0A158SIT3
      Related
      ENSMUSP00000109797.2, ENSMUST00000114160.2
      Conserved Domains (1) summary
      pfam04921
      Location:152338
      XAP5; circadian clock regulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      73356589..73363761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161770.1XP_036017663.1  protein FAM50A isoform X1

      UniProtKB/Swiss-Prot
      Q9D866, Q9WV03
      UniProtKB/TrEMBL
      A0A158SIT3
      Conserved Domains (1) summary
      pfam04921
      Location:152338
      XAP5; circadian clock regulator