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    PDR11 ATP-binding cassette multidrug transporter PDR11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854802, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PDR11
    Official Full Name
    ATP-binding cassette multidrug transporter PDR11
    Primary source
    SGD:S000001275
    Locus tag
    YIL013C
    See related
    AllianceGenome:SGD:S000001275; FungiDB:YIL013C; VEuPathDB:YIL013C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATPase-coupled transmembrane transporter activity. Involved in sterol import. Located in cell periphery. Is active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PDR11 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (328207..332442, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene alpha-1,3-mannosyltransferase MNT3 Neighboring gene uncharacterized protein Neighboring gene Tir3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP-binding cassette (ABC) transporters mediate nonvesicular, raft-modulated sterol movement from the plasma membrane to the endoplasmic reticulum. Li Y, et al. J Biol Chem, 2004 Oct 22. PMID 15316012
    2. The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: dehydroergosterol fluorescence study. Kohut P, et al. Biochem Biophys Res Commun, 2011 Jan 7. PMID 21110944
    3. Sterol uptake analysis in Saccharomyces and non-Saccharomyces wine yeast species. Tesnière C, et al. FEMS Yeast Res, 2021 Apr 7. PMID 33852000
    4. Mutations in the nucleotide-binding domain of putative sterol importers Aus1 and Pdr11 selectively affect utilization of exogenous sterol species in yeast. Papay M, et al. Yeast, 2020 Jan. PMID 31830308
    5. Steady state analysis of influx and transbilayer distribution of ergosterol in the yeast plasma membrane. Wüstner D. Theor Biol Med Model, 2019 Aug 15. PMID 31412941, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in the nucleotide-binding domain of putative sterol importers Aus1 and Pdr11 selectively affect utilization of exogenous sterol species in yeast.
      Title: Mutations in the nucleotide-binding domain of putative sterol importers Aus1 and Pdr11 selectively affect utilization of exogenous sterol species in yeast.
    2. Remarkably, and in contrast to Aus1p, ATPase activity of Pdr11p was insensitive to orthovanadate and not specifically stimulated by phosphatidylserine upon reconstitution into liposomes.
      Title: Purification and characterisation of the yeast plasma membrane ATP binding cassette transporter Pdr11p.
    3. Are2p, Aus1p, and Pdr11p, unlike the minor acyltransferase, Are1p, colocalize to sterol and sphingolipid-enriched, detergent-resistant microdomains (DRMs).
      Title: ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification.
    4. the entry of sterol molecules into plasma membrane is not spontaneous but requires assistance of two ABC (ATP-binding cassette) pumps--Aus1p or Pdr11p.
      Title: The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: dehydroergosterol fluorescence study.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase-coupled transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sterol import IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sterol import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette multidrug transporter PDR11
    NP_012252.1
    • ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      328207..332442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179363.1 → NP_012252.1  TPA: ATP-binding cassette multidrug transporter PDR11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012252.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVR7, P40550, Q03092
      UniProtKB/TrEMBL
      A6ZVQ5, B5VKS7, C7GJI3, G2WGD3, N1P1Q4
      Conserved Domains (1) summary
      TIGR00956
      Location:56 → 1381
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40550.3

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