Klk7 kallikrein related-peptidase 7 (chymotryptic, stratum corneum) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klk7provided by MGI
Official Full Name: kallikrein related-peptidase 7 (chymotryptic, stratum corneum)provided by MGI
Primary source: MGI:MGI:1346336
See related: Ensembl:ENSMUSG00000030713 AllianceGenome:MGI:1346336
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SCCE; Prss6
Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]
Expression: Biased expression in stomach adult (RPKM 6.8), mammary gland adult (RPKM 1.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.27 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43460718..43465811)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43811294..43816387)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation.
Title: Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation.
KLK7 is an important enzyme in the degradation and clearance of deposited Amyloid beta species by astrocytes involved in the pathogenesis of Alzheimer's disease.
Title: Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
A previously unrecognized role of KLK7 in adipose tissue with effects on whole body energy expenditure and insulin sensitivity.
Title: Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo.
Ablation of KLK7 is not sufficient to rescue the lethal effect of LEKTI-deficiency. Double deficiency of both KLK7 and KLK5 completely rescues Netherton Syndrome-like phenotype.
Title: KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
Higher hK7 expression is associated with cervical adenocarcinomas
Title: Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas.
Prolonged Klk7 neutralization provokes profound abnormalities in Klk7 function, due to pH-induced high serine protease activity that degrades lipid processing enzymes and corneodesmosomes proteins.
Title: Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1)

General gene information

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Markers

Klk7 (e-PCR), detects polymorphism
- UniSTS:502665

UniSTS:235957 (e-PCR)
- UniSTS:235957

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of antibacterial peptide production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of antibacterial peptide production	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in epidermal lamellar body	IEA Inferred from Electronic Annotation more info
located_in epidermal lamellar body	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-7

Names: kallikrein 7 (chymotryptic, stratum corneum); kallikrein-related peptidase 7; serine protease 6; stratum corneum chymotryptic enzyme; thymopsin

NP_036002.1

EC 3.4.21.117

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.