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    HAP1 Hap1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850958, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HAP1
    Official Full Name
    Hap1p
    Primary source
    SGD:S000004246
    Locus tag
    YLR256W
    See related
    AllianceGenome:SGD:S000004246; FungiDB:YLR256W; VEuPathDB:YLR256W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CYP1
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; establishment of protein localization to chromatin; and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HAP1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (646415..650923)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ndl1p Neighboring gene uncharacterized protein Neighboring gene gag protein Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HAP1 is nuclear but is bound to a cellular factor in the absence of heme. Zhang L, et al. J Biol Chem, 1994 May 20. PMID 8182072
    2. A hap1 mutation in a laboratory strain of Saccharomyces cerevisiae results in decreased expression of ergosterol-related genes and cellular ergosterol content compared to sake yeast. Tamura K, et al. J Biosci Bioeng, 2004. PMID 16233684
    3. The heme activator protein Hap1 represses transcription by a heme-independent mechanism in Saccharomyces cerevisiae. Hon T, et al. Genetics, 2005 Mar. PMID 15654089, Free PMC Article
    4. Control of Hap1-DNA site recognition through the interplay of multiple distinct intermolecular interactions. Wang LL, et al. Biochemistry, 2004 Nov 2. PMID 15504044
    5. The coiled coil dimerization element of the yeast transcriptional activator Hap1, a Gal4 family member, is dispensable for DNA binding but differentially affects transcriptional activation. Hach A, et al. J Biol Chem, 2000 Jan 7. PMID 10617612

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The activator/repressor Hap1 binds to the yeast eIF5A-encoding gene TIF51A to adapt its expression to the mitochondrial functional status.
      Title: The activator/repressor Hap1 binds to the yeast eIF5A-encoding gene TIF51A to adapt its expression to the mitochondrial functional status.
    2. Hap1 also plays a significant and direct role under hypoxic conditions, not as an activator, but as a repressor.
      Title: Heme levels switch the function of Hap1 of Saccharomyces cerevisiae between transcriptional activator and transcriptional repressor.
    3. analysis of a complex mechanism of transcriptional regulation at the HAP1 promoter, involving multiple DNA elements and regulatory proteins
      Title: Regulation of the HAP1 gene involves positive actions of histone deacetylases.
    4. Hap1 binds to DNA and activates transcription of genes encoding functions required for respiration and for controlling oxidative damage.
      Title: The heme activator protein Hap1 represses transcription by a heme-independent mechanism in Saccharomyces cerevisiae.
    5. A simultaneous optimization of distinct intermolecular interactions determines the DNA-binding specificity of Hap1. Perturbations to individual interactions modulate Hap1 binding affinity and, very likely, its binding geometry.
      Title: Control of Hap1-DNA site recognition through the interplay of multiple distinct intermolecular interactions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular respiration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hap1p
    NP_013357.1
    • Zinc finger transcription factor; involved in the complex regulation of gene expression in response to levels of heme and oxygen; localizes to the mitochondrion as well as to the nucleus; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      646415..650923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182143.1 → NP_013357.1  TPA: Hap1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013357.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYQ2, P0CE41, P0CS82
      Conserved Domains (3) summary
      cd12148
      Location:476 → 814
      fungal_TF_MHR; fungal transcription factor regulatory middle homology region
      smart00066
      Location:59 → 99
      GAL4; GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
      cd14655
      Location:99 → 130
      ZIP_Hap1; Leucine zipper Dimerization domain of transcription factor Hap1 and similar fungal proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CE41.1

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