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    Ccnc cyclin C [ Mus musculus (house mouse) ]

    Gene ID: 51813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccncprovided by MGI
    Official Full Name
    cyclin Cprovided by MGI
    Primary source
    MGI:MGI:1858199
    See related
    Ensembl:ENSMUSG00000028252 AllianceGenome:MGI:1858199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CG1C
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity and identical protein binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in several processes, including G0 to G1 transition; negative regulation of Notch signaling pathway; and negative regulation of triglyceride metabolic process. Part of mediator complex. Is expressed in central nervous system; limb; retina; and tongue. Orthologous to human CCNC (cyclin C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 5.3), CNS E14 (RPKM 4.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccnc in Genome Data Viewer
    Location:
    4 A3; 4 8.86 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21727705..21759917)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21727701..21759922)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57726 Neighboring gene STARR-seq mESC enhancer starr_09725 Neighboring gene PR domain containing 13 Neighboring gene STARR-seq mESC enhancer starr_09729 Neighboring gene STARR-seq mESC enhancer starr_09730 Neighboring gene STARR-positive B cell enhancer ABC_E3481 Neighboring gene STARR-seq mESC enhancer starr_09732 Neighboring gene STARR-seq mESC enhancer starr_09733 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 Neighboring gene ubiquitin specific petidase 45 Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene STARR-seq mESC enhancer starr_09734 Neighboring gene PNN interacting serine/arginine-rich

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. 3.6-KB mouse cyclin C promoter fragment is predominantly active in the testis. Blazsó P, et al. Acta Biol Hung, 2012 Mar. PMID 22453798
    2. Cyclin C mediates stress-induced mitochondrial fission and apoptosis. Wang K, et al. Mol Biol Cell, 2015 Mar 15. PMID 25609094, Free PMC Article
    3. The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription. Stieg DC, et al. J Biol Chem, 2020 Nov 27. PMID 32934007, Free PMC Article
    4. Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment. Jezek J, et al. EMBO Rep, 2019 Sep. PMID 31385392, Free PMC Article
    5. Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission. Ganesan V, et al. Mol Biol Cell, 2019 Feb 1. PMID 30516433, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics.
      Title: Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics.
    2. The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription.
      Title: The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription.
    3. his study uncovers new synergistic activities of Pten and cyclin C to promote quiescence through maintenance of p21 and p53.
      Title: Synergistic repression of thyroid hyperplasia by cyclin C and Pten.
    4. cyclin C binding stimulates the reduction of low-GTPase activity Drp1 oligomers into dimers capable of producing high-GTPase activity filaments.
      Title: Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission.
    5. these data indicate that CycC activates adipogenesis in part by stimulating the transcriptional activity of C/EBPalpha.
      Title: Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein α.
    6. our results suggest that mTORC1 activation in NAFLD and insulin resistance results in down-regulation of the CDK8-CycC complex and elevation of lipogenic protein expression.
      Title: mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).
    7. cyclin C connects stress-induced mitochondrial hyperfission and programmed cell death in mammalian cells.
      Title: Cyclin C mediates stress-induced mitochondrial fission and apoptosis.
    8. cyclin-C-CDK complexes phosphorylate the Notch1 intracellular domain (ICN1) and promote ICN1 degradation
      Title: Cyclin C is a haploinsufficient tumour suppressor.
    9. Data show that the isolated 3.6-KB promoter fragment alone is not sufficient for the complete physiological modulation of cyclin C RNA.
      Title: 3.6-KB mouse cyclin C promoter fragment is predominantly active in the testis.
    10. Results identify LSF as only the second known target (in addition to pRb) of cyclin C/CDK2 activity during progression from quiescence to early G(1).
      Title: Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CKM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CKM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-C
    Names
    dJ199J3.4 (cyclin C)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122982.3 → NP_001116454.1  cyclin-C isoform 2

      See identical proteins and their annotated locations for NP_001116454.1

      Status: VALIDATED

      Source sequence(s)
      AL772187
      Consensus CDS
      CCDS51127.1
      UniProtKB/TrEMBL
      Q05BN1, Q8CAS3
      Related
      ENSMUSP00000103875.3, ENSMUST00000108240.3
      Conserved Domains (2) summary
      cd20513
      Location:40 → 146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154 → 245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

    2. NM_001290420.2 → NP_001277349.1  cyclin-C isoform 3

      See identical proteins and their annotated locations for NP_001277349.1

      Status: VALIDATED

      Source sequence(s)
      AL772187
      Consensus CDS
      CCDS71350.1
      UniProtKB/TrEMBL
      Q05BN1, Q3UXL9
      Related
      ENSMUSP00000113682.2, ENSMUST00000120679.8
      Conserved Domains (1) summary
      cl28538
      Location:1 → 212
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

    3. NM_001290422.2 → NP_001277351.1  cyclin-C isoform 2

      See identical proteins and their annotated locations for NP_001277351.1

      Status: VALIDATED

      Source sequence(s)
      AL772187
      Consensus CDS
      CCDS51127.1
      UniProtKB/TrEMBL
      Q05BN1, Q8CAS3
      Related
      ENSMUSP00000069076.5, ENSMUST00000065928.11
      Conserved Domains (2) summary
      cd20513
      Location:40 → 146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154 → 245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

    4. NM_001424981.1 → NP_001411910.1  cyclin-C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL772187

    5. NM_001424982.1 → NP_001411911.1  cyclin-C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL772187
      UniProtKB/TrEMBL
      Q05C55

    6. NM_001424983.1 → NP_001411912.1  cyclin-C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL772187

    7. NM_016746.5 → NP_058026.2  cyclin-C isoform 1

      See identical proteins and their annotated locations for NP_058026.2

      Status: VALIDATED

      Source sequence(s)
      AL772187
      Consensus CDS
      CCDS17998.1
      UniProtKB/Swiss-Prot
      Q0P542, Q5XKQ9, Q62447, Q9WUZ4
      UniProtKB/TrEMBL
      Q497T2
      Related
      ENSMUSP00000100062.2, ENSMUST00000102997.8
      Conserved Domains (2) summary
      cd20513
      Location:40 → 146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154 → 245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      21727705..21759917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164233.1 → XP_036020126.1  cyclin-C isoform X1

      UniProtKB/TrEMBL
      Q497T2
      Conserved Domains (2) summary
      cd20513
      Location:33 → 139
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:147 → 238
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

    2. XM_036164234.1 → XP_036020127.1  cyclin-C isoform X2

      UniProtKB/TrEMBL
      Q05BN1
      Conserved Domains (2) summary
      cd20513
      Location:33 → 139
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:147 → 238
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62447.4 GenPept UniProtKB/Swiss-Prot:Q62447

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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