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    RCN1 Rcn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853698, updated on 17-Dec-2024

    Summary

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    Official Symbol
    RCN1
    Official Full Name
    Rcn1p
    Primary source
    SGD:S000001642
    Locus tag
    YKL159C
    See related
    AllianceGenome:SGD:S000001642; FungiDB:YKL159C; VEuPathDB:YKL159C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables calcium-dependent protein serine/threonine phosphatase regulator activity and protein phosphatase 2B binding activity. Involved in calcium-mediated signaling. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN3 (RCAN family member 3); RCAN1 (regulator of calcineurin 1); and RCAN2 (regulator of calcineurin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RCN1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (153816..154451, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene putative protein kinase KDX1 Neighboring gene Elf1p Neighboring gene metallo-aminopeptidase Neighboring gene ribosomal 40S subunit protein S27A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. Görlach J, et al. EMBO J, 2000 Jul 17. PMID 10899116, Free PMC Article
    2. GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Hilioti Z, et al. Genes Dev, 2004 Jan 1. PMID 14701880, Free PMC Article
    3. Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. Reedy JL, et al. Fungal Genet Biol, 2010 Feb. PMID 19755168, Free PMC Article
    4. Identification of RCN1 and RSA3 as ethanol-tolerant genes in Saccharomyces cerevisiae using a high copy barcoded library. Anderson MJ, et al. FEMS Yeast Res, 2012 Feb. PMID 22093065
    5. Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast. Mehta S, et al. Mol Cell Biol, 2009 May. PMID 19273587, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors find that increased dosage of either RCN1 or RSA3 improves tolerance of S288C and M2 to toxic levels of ethanol.
      Title: Identification of RCN1 and RSA3 as ethanol-tolerant genes in Saccharomyces cerevisiae using a high copy barcoded library.
    2. identify the molecular mechanism of Rcn1 phosphorylation-induced stimulation of the phosphatase activity of calcineurin
      Title: The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent protein serine/threonine phosphatase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein phosphatase 2B binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rcn1p
    NP_012763.1
    • Noncompetitive calcineurin inhibitor involved in calcium-mediated signaling; homolog of human DSCR1, a regulator of calcineurin (RCAN) located in the Down Syndrome candidate region on chromosome 21

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      153816..154451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179725.1 → NP_012763.1  TPA: Rcn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012763.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX40, P36054
      UniProtKB/TrEMBL
      A6ZZG5, B3LQU6, B5VM07, C7GT77, C8ZC16, G2WHN2, N1P8A7
      Conserved Domains (1) summary
      pfam04847
      Location:17 → 201
      Calcipressin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36054.1

    Gene LinkOut

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