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    HHF2 histone H4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HHF2
    Official Full Name
    histone H4
    Primary source
    SGD:S000004975
    Locus tag
    YNL030W
    See related
    AllianceGenome:SGD:S000004975; FungiDB:YNL030W; VEuPathDB:YNL030W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in chromatin organization. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. Orthologous to several human genes including H4C1 (H4 clustered histone 1); H4C11 (H4 clustered histone 11); and H4C12 (H4 clustered histone 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HHF2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (576727..577038)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative tyrosine protein phosphatase SIW14 Neighboring gene histone H3 Neighboring gene putative mannosyltransferase Neighboring gene DNA-binding transcription factor CRZ1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of novel histone post-translational modifications by peptide mass fingerprinting. Zhang L, et al. Chromosoma, 2003 Aug. PMID 12937907
    2. A genomic integration method for the simultaneous visualization of endogenous mRNAs and their translation products in living yeast. Haim-Vilmovsky L, et al. RNA, 2011 Dec. PMID 22025736, Free PMC Article
    3. Stable nucleosome positioning and complete repression by the yeast alpha 2 repressor are disrupted by amino-terminal mutations in histone H4. Roth SY, et al. Genes Dev, 1992 Mar. PMID 1547940
    4. Partial depletion of histone H4 increases homologous recombination-mediated genetic instability. Prado F, et al. Mol Cell Biol, 2005 Feb. PMID 15684401, Free PMC Article
    5. Quantification of acetylation at proximal lysine residues using isotopic labeling and tandem mass spectrometry. Smith CM. Methods, 2005 Aug. PMID 16098763

    See all (391) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that DNA replication largely results in nucleosomes bearing exclusively old or new H3-H4.
      Title: Splitting of H3-H4 tetramers at transcriptionally active genes undergoing dynamic histone exchange.
    2. analysis of the histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae
      Title: Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone H4
    NP_014368.1
    • Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      576727..577038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182869.1 → NP_014368.1  TPA: histone H4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014368.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ10, P02309
      UniProtKB/TrEMBL
      A6ZKV6, B3LND1, C7GM41, C8Z404, C8ZFK7, G2W917, N1PAQ9
      Conserved Domains (1) summary
      PTZ00015
      Location:18 → 101
      PTZ00015; histone H4; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02309.2

    Gene LinkOut

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